P-909

甲氨蝶呤-D_{4标准液 CRM} 溶液

100 μg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant^®

• 经验公式（希尔记法）: C₈D₄H₅NO₂
• CAS号: 64315-36-2
• 分子量: 155.19
• EC號碼: 200-659-6
• 分類程式碼代碼: 41116107
• NACRES: NA.24

属性

• 等級: certified reference material
• 形狀: liquid
• 特點: Snap-N-Spike^®/Snap-N-Shoot^®
• 包裝: ampule of 1 mL
• 製造商／商標名: Cerilliant^®
• 濃度: 100 μg/mL in methanol
• 技術: gas chromatography (GC): suitable; liquid chromatography (LC): suitable
• 應用: forensics and toxicology
• 格式: single component solution
• 儲存溫度: −20°C
• SMILES 字串: [2H]c1c([2H])c(NC(C)=O)c([2H])c([2H])c1O
• InChI: 1S/C8H9NO2/c1-6(10)9-7-2-4-8(11)5-3-7/h2-5,11H,1H3,(H,9,10)/i2D,3D,4D,5D
• InChI 密鑰: RZVAJINKPMORJF-QFFDRWTDSA-N

说明

一般說明

稳定标记的内标，适用于 尿液、血清或血浆中的对乙酰氨基酚水平的 LC/MS 或 GC/MS 定量，以进行临床毒理学、同位素稀释方法、P450 研究和其他药物研究。对乙酰氨基酚（或对扑热息痛）是一种常用的非处方 COX 抑制剂，用于止痛和退烧。

應用

• Simultaneous determination of acetaminophen and oxycoDonein human plasma by LC-MS/MS and its application to a pharmacokinetic study: Highlights the application of acetaminophen-D₄ as an internal standard in pharmacokinetic studies to ensure accurate measurement of drug levels in plasma, crucial for drug development and therapeutic monitoring (Lu et al., 2018).


• Simultaneous quantification of acetaminophen and five acetaminophen metabolites in human plasma and urine by high-performance liquid chromatography-electrospray ionization-tandem mass spectrometry: Demonstrates the use of acetaminophen-D₄ in complex bioanalytical methods for studying drug metabolism and excretion in clinical pharmacology (Cook et al., 2015).


• Application of high-performance liquid chromatography/chemical reaction interface mass spectrometry for the analysis of conjugated metabolites: Discusses a method using deuterated acetaminophen (such as acetaminophen-D₄) to analyze conjugated drug metabolites, enhancing the understanding of drug metabolism pathways (Teffera and Abramson, 1994).


• Acetaminophen production in man after coadministration of acetanilid and phenacetin: A study that possibly uses deuterated compounds like acetaminophen-D₄ to trace metabolic pathways and interactions between multiple analgesics, providing insights into their pharmacokinetic behaviors (Baty and Robinson, 1977).

法律資訊

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany

Snap-N-Shoot is a registered trademark of Cerilliant Corporation

Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

安全信息

• 象形圖: GHS02,GHS06,GHS08
• 訊號詞: Danger
• 危險聲明: H225,H301 + H311 + H331,H370
• 防範說明: P210 - P280 - P301 + P310 + P330 - P302 + P352 + P312 - P304 + P340 + P311
• 危險分類: Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
• 標靶器官: Eyes
• 儲存類別代碼: 3 - Flammable liquids
• 水污染物質分類（WGK）: WGK 1
• 閃點（°F）: 49.5 °F - closed cup
• 閃點（°C）: 9.7 °C - closed cup