QBD10194

NHS-S-S-dPEG^®₄-biotin (cleavable)

• 别名: 2,5-Dioxo-1-pyrrolidinyl 29-[(3aS,4S,6aR)-hexahydro-2-oxo-1H-thieno[3,4-d]imidazol-4-yl]-9,25-dioxo-12,15,18,21-tetraoxa-4,5-dithia-8,24-diazanonacosanoate, Polyethylene glycol
• 经验公式（希尔记法）: C₃₀H₄₉N₅O₁₁S₃
• CAS号: 1260247-51-5
• 分子量: 751.93
• 分類程式碼代碼: 51171641
• PubChem物質ID: 329823886
• NACRES: NA.22

属性

• 化驗: >90%
• 形狀: solid or viscous liquid
• 反應適用性: reaction type: Biotinylations; reagent type: cross-linking reagent
• 官能基: disulfide
• 聚合物結構: shape: linear; functionality: monofunctional
• 運輸包裝: ambient
• 儲存溫度: −20°C
• SMILES 字串: O=C(NCCSSCCC(ON1C(CCC1=O)=O)=O)CCOCCOCCOCCOCCNC(CCCCC2C3NC(NC3CS2)=O)=O

说明

特點和優勢

NHS-S-S-dPEG^®₄-biotin is used extensively to label molecules that contain a free amine with biotin. This dPEG^® spacer imparts a high degree of water solubility to the biotin label. For biotinylated peptides and proteins, the dPEG^® spacer dramatically reduces aggregation and precipitation of the modified molecule and reduces non-specific binding of the molecule, both of which are common problems with molecules that have been biotinylated with the widely used NHS-LC-biotin. NHS-S-S-dPEG^®₄-biotin contains a disulfide group in the linear chain, allowing the biotin to be cleaved reductively from the labeled molecule.

法律資訊

Products Protected under U.S. Patents # 7,888,536 B2

dPEG is a registered trademark of Quanta BioDesign

安全信息

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable