跳转至内容
Merck

MDC1

mediator of DNA-damage checkpoint 1

别名:
NFBD1
物种:
UniProtKB ID:
基因ID:
  • Human(9656) Summary: The protein encoded by this gene contains an N-terminal forkhead domain, two BRCA1 C-terminal (BRCT) motifs and a central domain with 13 repetitions of an approximately 41-amino acid sequence. The encoded protein is required to activate the intra-S phase and G2/M phase cell cycle checkpoints in response to DNA damage. This nuclear protein interacts with phosphorylated histone H2AX near sites of DNA double-strand breaks through its BRCT motifs, and facilitates recruitment of the ATM kinase and meiotic recombination 11 protein complex to DNA damage foci. [provided by RefSeq, Jul 2008]
  • Mouse(240087) mediator of DNA damage checkpoint 1
  • Rat(309595) mediator of DNA damage checkpoint 1
  • chicken(101664732) mediator of DNA-damage checkpoint 1
  • chicken(101751335) mediator of DNA-damage checkpoint 1
  • cow(511168) mediator of DNA-damage checkpoint 1
  • Horse(100055473) mediator of DNA-damage checkpoint 1
  • domestic cat(101095415) mediator of DNA-damage checkpoint 1
  • dog(474829) mediator of DNA-damage checkpoint 1
  • sheep(101107143) mediator of DNA-damage checkpoint 1
  • domestic guinea pig(100721744) mediator of DNA-damage checkpoint 1
  • naked mole-rat(101702518) mediator of DNA-damage checkpoint 1

Custom & Knockdown Gene Products

  • siRNA

    Shop predesigned siRNA that are designed using the proprietary Rosetta Inpharmatics algorithm.

  • shRNA

    Shop the largest, most validated shRNA collection and build your own clone sets.

  • Custom Gene Products

    We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.

Antibodies

货号
说明
物种反应性
应用
Anti-MDC1 antibody, Mouse monoclonal, clone MDC1-50, purified from hybridoma cell culture,
物种反应性
human, monkey
应用
immunocytochemistry
immunoprecipitation (IP)

microarray

western blot
Rabbit anti-MDC1 Antibody, Affinity Purified, Powered by Bethyl Laboratories, Inc.,
物种反应性
human
应用
immunoprecipitation (IP)
western blot
ANTI-MDC1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
物种反应性
human
应用
immunofluorescence
immunohistochemistry
Anti-phospho-MDC1 (pSer513) antibody produced in rabbit, affinity isolated antibody,
物种反应性
human
应用
immunohistochemistry
Monoclonal Anti-MDC1 antibody produced in mouse, clone P2B11, 1 mg/mL, purified immunoglobulin,
物种反应性
bovine, chimpanzee, human, mouse
应用
immunofluorescence
western blot

esiRNA

货号
说明
物种
MISSION® esiRNA, targeting mouse Mdc1,
物种
mouse
MISSION® esiRNA, targeting human MDC1,
物种
human