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Merck

HLA-B

major histocompatibility complex, class I, B

别名:
AS, HLAB, SPDA1
物种:
Human HLA-B (3106)
UniProtKB ID:
P30464, B0V0B8, P30465, P30513, Q29633, Q29636, Q29829, Q29953
基因ID:
  • Human(3106) Summary: HLA-B belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exon 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-B alleles have been described. [provided by RefSeq, Jul 2008]

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Antibodies

货号
说明
物种反应性
应用
SAB1410631
Anti-HLA-B antibody produced in rabbit, purified immunoglobulin, buffered aqueous solution,
物种反应性
human
应用
western blot
SAB1405937
Anti-HLA-B antibody produced in mouse, purified immunoglobulin, buffered aqueous solution,
物种反应性
human
应用
western blot
H1650
抗HLA I类抗原单克隆抗体 小鼠抗, clone W6/32, purified immunoglobulin, buffered aqueous solution,
物种反应性
human, monkey
应用
flow cytometry
immunofluorescence
immunoprecipitation (IP)
SAB4700638
Monoclonal Anti-HLA Class I-Biotin antibody produced in mouse, clone W6/32, purified immunoglobulin, buffered aqueous solution,
物种反应性
human
应用
flow cytometry
F5662
抗HLA I类抗原单克隆抗体, clone W6/32, purified immunoglobulin, buffered aqueous solution,
物种反应性
human, monkey
应用
flow cytometry
immunofluorescence