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Merck

GRIN2C

glutamate receptor, ionotropic, N-methyl D-aspartate 2C

别名:
GluN2C, NMDAR2C, NR2C
物种:
UniProtKB ID:
基因ID:
  • Human(2905) Summary: This gene encodes a subunit of the N-methyl-D-aspartate (NMDA) receptor, which is a subtype of ionotropic glutamate receptor. NMDA receptors are found in the central nervous system, are permeable to cations and have an important role in physiological processes such as learning, memory, and synaptic development. The receptor is a tetramer of different subunits (typically heterodimer of subunit 1 with one or more of subunits 2A-D), forming a channel that is permeable to calcium, potassium, and sodium, and whose properties are determined by subunit composition. Alterations in the subunit composition of the receptor are associated with pathophysiological conditions such as Parkinson's disease, Alzheimer's disease, depression, and schizophrenia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]
  • Mouse(14813) glutamate receptor, ionotropic, NMDA2C (epsilon 3)
  • Rat(24411) glutamate receptor, ionotropic, N-methyl D-aspartate 2C
  • sheep(101102915) glutamate receptor, ionotropic, N-methyl D-aspartate 2C
  • domestic guinea pig(100721967) glutamate receptor, ionotropic, N-methyl D-aspartate 2C
  • naked mole-rat(101698922) glutamate receptor, ionotropic, N-methyl D-aspartate 2C
  • chicken(431090) glutamate receptor, ionotropic, N-methyl D-aspartate 2C
  • dog(483302) glutamate receptor, ionotropic, N-methyl D-aspartate 2C
  • cow(535158) glutamate receptor, ionotropic, N-methyl D-aspartate 2C
  • domestic cat(101091740) glutamate receptor, ionotropic, N-methyl D-aspartate 2C

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Small Molecule - Agonist

货号
说明
物种
L-酪氨酸 盐酸盐, ≥98% (TLC),
物种
mouse, rat, human
D-环丝氨酸, synthetic,
物种
human
右美沙芬 氢溴酸盐 一水合物, ≥99% (TLC),
物种
human
N-甲基- D -天冬氨酸, ≥98% (TLC), solid,
物种
human, rat
D-环丝氨酸, ,
物种
human, mouse, rat

Small Molecule - Allosteric Modulator

货号
说明
物种
阿坎酸钙, ≥98% (HPLC), powder,
物种
human
阿坎酸钙, United States Pharmacopeia (USP) Reference Standard, monograph mol wt. 400.48 (C10H20CaN2O8S2),
物种
human
阿坎酸钙, British Pharmacopoeia (BP) Reference Standard,
物种
human

Small Molecule - Antagonist

货号
说明
物种
D(-)-2-氨基-5-膦戊酸, NMDA receptor antagonist,
物种
mouse, rat
右啡烷 酒石酸酯, powder,
物种
human
艾芬地尔 (+)-酒石酸盐, ,
物种
human
魁蛤素 硫酸盐, ,
物种
human
DL-2-氨基-4-磷丁酸, solid,
物种
rat, human

Antibodies

货号
说明
物种反应性
应用
Anti-GRIN2C antibody produced in mouse, purified immunoglobulin, buffered aqueous solution,
物种反应性
human
应用
western blot
抗-谷氨酸受体NMDAR2C(NR2C) 兔抗, affinity isolated antibody, lyophilized powder,
物种反应性
human, mouse, rat
应用
immunofluorescence
immunohistochemistry

immunoprecipitation (IP)

western blot

Small Molecule - Blocker

货号
说明
物种
N-(3,3-Diphenylpropyl)glycinamide, >98% (HPLC), solid,
物种
human
胍丁胺 硫酸盐, ≥97%, powder,
物种
human
奥芬那君 盐酸盐, ≥98.0% (AT),
物种
human
奥芬那君 盐酸盐, European Pharmacopoeia (EP) Reference Standard,
物种
human
奥芬那君 盐酸盐, European Pharmacopoeia (EP) Reference Standard,
物种
human

Small Molecule - Inhibitor

货号
说明
物种
喷他脒 羟乙基磺酸盐, powder,
物种
human
奥芬那君 盐酸盐, ≥98.0% (AT),
物种
human
奥芬那君 盐酸盐, European Pharmacopoeia (EP) Reference Standard,
物种
human
奥芬那君 盐酸盐, European Pharmacopoeia (EP) Reference Standard,
物种
human

esiRNA

货号
说明
物种
MISSION® esiRNA, targeting human GRIN2C,
物种
human