跳转至内容
Merck

ERBB2

v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2

别名:
CD340, HER-2, HER-2/neu, HER2, MLN 19, NEU, NGL, TKR1
物种:
UniProtKB ID:
基因ID:
  • Human(2064) Summary: This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq, Jul 2008]
  • Mouse(13866) v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)
  • Rat(24337) v-erb-b2 avian erythroblastic leukemia viral oncogene 2
  • sheep(780519) v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)
  • Domestic Rabbit(100009554) v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)
  • naked mole-rat(101705227) v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)
  • domestic guinea pig(100727657) v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)
  • Zebrafish(386966) v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog
  • cow(505709) v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2
  • Horse(100054739) v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)
  • domestic cat(751824) v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)
  • dog(403883) v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)
  • chicken(426130) v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog

Custom & Knockdown Gene Products

  • siRNA

    Shop predesigned siRNA that are designed using the proprietary Rosetta Inpharmatics algorithm.

  • shRNA

    Shop the largest, most validated shRNA collection and build your own clone sets.

  • Custom Gene Products

    We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.

ELISA

货号
说明
物种
人ErbB2 / HER2 ELISA试剂盒, for serum, plasma, cell culture supernatant and urine,
物种
human

Antibodies

货号
说明
物种反应性
应用
抗-ERBB2 兔抗, Ab1, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
物种反应性
human
应用
immunofluorescence
immunohistochemistry

western blot
Monoclonal Anti-c-erbB-2 antibody produced in mouse, ~2 mg/mL, clone HER2-96, purified immunoglobulin, buffered aqueous solution,
物种反应性
human
应用
ELISA
immunoprecipitation (IP)

microarray
Anti-C-ERBB-2/HER-2 antibody, Rabbit monoclonal, recombinant, expressed in proprietary host, clone SP3, tissue culture supernatant,
物种反应性
dog, hamster, human, mouse, rat
应用
immunohistochemistry
Anti-HER2 antibody produced in rabbit, affinity isolated antibody,
物种反应性
human, mouse, rat
应用
ELISA
immunohistochemistry

western blot
Anti-HER2 antibody produced in rabbit, affinity isolated antibody,
物种反应性
human, mouse, rat
应用
ELISA
immunohistochemistry

western blot

Small Molecule - Inhibitor

货号
说明
物种
Mubritinib, ≥98% (HPLC),
物种
human
CP724714, ≥98% (HPLC),
物种
human
拉帕替尼, ≥98% (HPLC),
物种
human
拉帕替尼, ,
物种
human
Tyrphostin AG 879, 99% (HPLC),
物种
human

Proteins

货号
说明
物种
HER2 (676-end), active, GST tagged human, PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution,
物种
human

esiRNA

货号
说明
物种
MISSION® esiRNA, targeting human ERBB2,
物种
human
MISSION® esiRNA, targeting mouse Erbb2,
物种
mouse