跳转至内容
Merck

CCM2

cerebral cavernous malformation 2

别名:
C7orf22, OSM
物种:
UniProtKB ID:
基因ID:
  • Human(83605) Summary: This gene encodes a scaffold protein that functions in the stress-activated p38 Mitogen-activated protein kinase (MAPK) signaling cascade. The protein interacts with SMAD specific E3 ubiquitin protein ligase 1 (also known as SMURF1) via a phosphotyrosine binding domain to promote RhoA degradation. The protein is required for normal cytoskeletal structure, cell-cell interactions, and lumen formation in endothelial cells. Mutations in this gene result in cerebral cavernous malformations. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Nov 2009]
  • Mouse(216527) cerebral cavernous malformation 2
  • Rat(305505) cerebral cavernous malformation 2
  • Zebrafish(436586) cerebral cavernous malformation 2
  • chicken(420410) cerebral cavernous malformation 2
  • cow(506450) cerebral cavernous malformation 2
  • Horse(100065340) cerebral cavernous malformation 2
  • domestic cat(101100375) cerebral cavernous malformation 2
  • dog(475502) cerebral cavernous malformation 2
  • domestic guinea pig(100716240) cerebral cavernous malformation 2
  • naked mole-rat(101711971) cerebral cavernous malformation 2
  • sheep(101114100) cerebral cavernous malformation 2

Custom & Knockdown Gene Products

  • siRNA

    Shop predesigned siRNA that are designed using the proprietary Rosetta Inpharmatics algorithm.

  • shRNA

    Shop the largest, most validated shRNA collection and build your own clone sets.

  • Custom Gene Products

    We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.

Antibodies

Product Number
说明
物种反应性
应用
Anti-CCM2 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
物种反应性
human
应用
immunofluorescence
Anti-CCM2 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution, Ab1,
物种反应性
human
应用
immunofluorescence
immunohistochemistry
Anti-CCM2 antibody produced in goat, affinity isolated antibody, buffered aqueous solution,
物种反应性
canine, human, mouse, rat
应用
ELISA
western blot
Anti-CCM2 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution, Ab2,
物种反应性
human
应用
immunohistochemistry
Anti-CCM2 antibody produced in mouse, IgG fraction of antiserum, buffered aqueous solution,
物种反应性
human
应用
western blot

esiRNA

Product Number
说明
物种
MISSION® esiRNA, targeting mouse Ccm2,
物种
mouse
MISSION® esiRNA, targeting human CCM2,
物种
human