Empowering Tomorrow’s Therapeutics with LC-MS Capillary Chromatography

WEBINAR

This webinar, hosted by Separation Science, emphasizes the significance of capillary HPLC coupled with mass spectrometry in two parts. The first part discusses our Lipidomics Analytical Platform for mRNA Lipid Nanoparticle (LNP) Innovation, aiming to study LNP metabolization and predict metabolites for regulatory approval of LNP-based therapeutics. The second part focuses on the use of liquid chromatography-mass spectrometry (LC-MS) as a powerful tool for studying organoids and organ-on-chip (OoC) models. These models, used as alternatives to animal models, require sensitive analytical tools, and LC-MS methods for proteomics, lipidomics, peptidomics, and drug metabolism studies are being developed and applied for this purpose. The presentation also highlights the advantages of miniaturization of the LC system and on-line analysis for sensitive and automated measurements with minimal sample loss and contamination.

By watching the presentation, you will learn:

• How to develop sensitive and selective LC-MS analysis of organoids
• How to tailor sample preparation procedures to fit the uniqueness of such biosamples
• How to proceed with method validation