70% of APIs under development are poorly water soluble, which increases the risk of them failing during formulation. Co-crystallization is a rapidly growing technique used to tackle solubility challenges. However, it is challenging and resource intensive to find new co-crystals experimentally.
In recent years, several approaches have been developed to screen for co-crystals computationally. We developed mPredict™, a co-crystal prediction tool with quantum chemistry, statistical thermodynamics, and AI. It predicts co-crystal formation and, hence, optimal co-formers for your API. Besides being a strong improvement over physical modelling, it is also three times faster than random digital screening.
In this webinar, you will learn about:
- why co-crystallization is rapidly growing as a technique to tackle solubility challenges
- the challenges of co-crystallization and ways to overcome them
- the key technical considerations to build a co-former screening tool
- the advantages of using our cutting edge mPredict™ co-crystal prediction service
Speaker
Mitali Bhagwat
Merck
Strategic Product Manager – Excipients Solid Application
Mitali has a master's degree in pharmaceutical sciences with several years of work experience in the pharma industry on generic product development and filing. With a degree in intellectual property, she previously worked on developing IP strategies. After completing her MBA in international management and consulting in the pharma industry, she now works at Merck as a strategic product manager. Her responsibility lies in the field of excipients used for solid formulation drug development wherein she is leading the digital strategy with its flagship product mPredict™.
Pharma and biopharma manufacturing
- Liquid Formulation Strategies
期间:1h
语言:English
场次 1:往期 November 19, 2024
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