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Merck

[The calcipotriol-betamethasone dipropionate association].

Revue medicale de Liege (2006-01-13)
F Henry, C Flagothier, P Delvoye, C Piérard-Franchimont, G E Piérard
ABSTRACT

The topical treatment of psoriasis benefits from the alternate use of dermocorticosteroids and vitamin D3 analogues. A new galenic formulation allows to combine them in a single application. Dovobet (LEO Pharma) ointment is the association of calcipotriol 50 microg/g with betamethasone dipoprionate 0.5 mg/g. This formulation boosts the therapeutic activity of calcipotriol. It also decreases the irritative inflammatory reaction due to calcipotriol without increasing the atrophogenic risk of the dermocorticoid.

MATERIALS
Product Number
Brand
Product Description

Betamethasone dipropionate for peak identification, European Pharmacopoeia (EP) Reference Standard
Supelco
Betamethasone, VETRANAL®, analytical standard
Betamethasone dipropionate, European Pharmacopoeia (EP) Reference Standard
Betamethasone, European Pharmacopoeia (EP) Reference Standard
Supelco
Betamethasone, Pharmaceutical Secondary Standard; Certified Reference Material
Supelco
Betamethasone Dipropionate, Pharmaceutical Secondary Standard; Certified Reference Material
USP
Betamethasone dipropionate, United States Pharmacopeia (USP) Reference Standard
Sigma-Aldrich
Betamethasone, ≥98%
Sigma-Aldrich
Betamethasone 17,21-dipropionate