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SML3517

Sigma-Aldrich

Fluindione

≥98% (HPLC)

Synonym(s):

2-(4-Fluorophenyl)-1H-indene-1,3(2H)-dione, 2-(4-Fluorophenyl)indene-1,3-dione

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About This Item

Empirical Formula (Hill Notation):
C15H9FO2
CAS Number:
957-56-2
Molecular Weight:
240.23
MDL number:
MFCD00239202
UNSPSC Code:
51111800
UNSPSC Code:
12352200
NACRES:
NA.77

Quality Level

100

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

O=C1C2=C(C(C1C3=CC=C(C=C3)F)=O)C=CC=C2

InChI

1S/C15H9FO2/c16-10-7-5-9(6-8-10)13-14(17)11-3-1-2-4-12(11)15(13)18/h1-8,13H

InChI key

NASXCEITKQITLD-UHFFFAOYSA-N

Biochem/physiol Actions

Fluindione is an orally active vitamin K antagonist (VKA) that exerts its in vivo anticoagulant efficacy by inhibiting the vitamin K epoxide reductase activity (VKOR IC50 = 6.6 nM) in a substrate-comeptitive manner.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Xuejie Chen et al.
Blood, 132(18), 1974-1984 (2018-08-10)
Warfarin, acenocoumarol, phenprocoumon, and fluindione are commonly prescribed oral anticoagulants for the prevention and treatment of thromboembolic disorders. These anticoagulants function by impairing the biosynthesis of active vitamin K-dependent coagulation factors through the inhibition of vitamin K epoxide reductase (VKOR).

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