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Key Documents

SAB1401644

Sigma-Aldrich

Anti-SESN1 antibody produced in rabbit

purified immunoglobulin, buffered aqueous solution

Synonym(s):

MGC138241, MGC142129, PA26, RP11-787I22.1, SEST1

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

human

technique(s)

western blot: 1 μg/mL

NCBI accession no.

NM_014454

UniProt accession no.

Q9Y6P5

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... SESN1(27244)

Immunogen

SESN1 (NP_055269.1, 1 a.a. ~ 551 a.a) full-length human protein.

Sequence
MAEGENEVRWDGLCSRDSTTRETALENIRQTILRKTEYLRSVKETPHRPSDGLSNTESSDGLNKLLAHLLMLSKRCPFKDVREKSEFILKSIQELGIRIPRPLGQGPSRFIPEKEILQVGSEDAQMHALFADSFAALGRLDNITLVMVFHPQYLESFLKTQHYLLQMDGPLPLHYRHYIGIMAAARHQCSYLVNLHVNDFLHVGGDPKWLNGLENAPQKLQNLGELNKVLAHRPWLITKEHIEGLLKAEEHSWSLAELVHAVVLLTHYHSLASFTFGCGISPEIHCDGGHTFRPPSVSNYCICDITNGNHSVDEMPVNSAENVSVSDSFFEVEALMEKMRQLQECRDEEEASQEEMASRFEIEKRESMFVFSSDDEEVTPARAVSRHFEDTSYGYKDFSRHGMHVPTFRVQDYCWEDHGYSLVNRLYPDVGQLIDEKFHIAYNLTYNTMAMHKDVDTSMLRRAIWNYIHCMFGIRYDDYDYGEINQLLDRSFKVYIKTVVCTPEKVTKRMYDSFWRQFKHSEKVHVNLLLIEARMQAELLYALRAITRYMT

Biochem/physiol Actions

Sesn1 (sestrin 1) is known to be a protein involved in sensing stress. It promotes the AMPK (5′ AMP-activated protein kinase) activation. Sesn1 inhibits mTORC1 (mammalian target of rapamycin complex 1) signaling, thereby contributing to anti-ageing mechanism. Sestrins protein family possesses oxidoreductase activity. Sestrins are believed to promote antioxidative responses to stress, as they are transcripted by p53 (tumor protein) and FoxO (Forkhead box). Thus, they can serve as a potential therapeutic target.

Physical form

Solution in phosphate buffered saline, pH 7.4

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Storage Class Code

10 - Combustible liquids

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Alessio Lanna et al.
Nature immunology, 18(3), 354-363 (2017-01-24)
Mitogen-activated protein kinases (MAPKs) including Erk, Jnk and p38 regulate diverse cellular functions and are thought to be controlled by independent upstream activation cascades. Here we show that the sestrins bind to and coordinate simultaneous Erk, Jnk and p38 MAPK
Regeneration of peroxiredoxins by p53-regulated sestrins, homologs of bacterial AhpD.
Budanov AV
Science, 304(5670), 596-600 (2004)
Junxia Zhang et al.
Mediators of inflammation, 2014, 769608-769608 (2014-03-04)
Studies indicate the dramatic reduction of shear stress (SS) within the rapamycin eluting stent (RES) segment of coronary arteries. It remains unclear about the role of rapamycin in endothelialization of stented arteries where SS becomes low. Since mTOR (mammalian target
Andrei V Budanov et al.
Science (New York, N.Y.), 304(5670), 596-600 (2004-04-24)
Acting as a signal, hydrogen peroxide circumvents antioxidant defense by overoxidizing peroxiredoxins (Prxs), the enzymes that metabolize peroxides. We show that sestrins, a family of proteins whose expression is modulated by p53, are required for regeneration of Prxs containing Cys-SO(2)H
High Expression of LAMP3 Is a Novel Biomarker of Poor Prognosis in Patients with Esophageal Squamous Cell Carcinoma.
Liao X
International Journal of Molecular Sciences, 16(8), 1-13 (2015)
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