G9003

D-Glutamine

≥98% (HPLC)

• Synonym(s): D-2-Aminoglutaramic acid, D-Glutamic acid 5-amide
• Empirical Formula (Hill Notation): C₅H₁₀N₂O₃
• CAS Number: 5959-95-5
• Molecular Weight: 146.14
• Beilstein: 1723796
• MDL number: MFCD00065607
• UNSPSC Code: 12352209
• PubChem Substance ID: 24895357
• NACRES: NA.32

Properties

• product name: D-Glutamine, ≥98% (HPLC)
• Assay: ≥98% (HPLC)
• form: powder
• color: white
• application(s): cell analysis
• SMILES string: N[C@H](CCC(N)=O)C(O)=O
• InChI: 1S/C5H10N2O3/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H2,7,8)(H,9,10)/t3-/m1/s1
• InChI key: ZDXPYRJPNDTMRX-GSVOUGTGSA-N

Description

General description

Glutamine is a non-essential and the most abundant free amino acid present in the human body. It is an important component of proteins and is one of the 20 proteinogenic amino acids. It forms 5-6% of bound amino acids.

Application

D-Glutamine has been used to study its role in conferring protection against acetaldehyde-induced disruption of barrier function in Caco-2 cell monolayer.

Biochem/physiol Actions

Glutamine forms the central metabolite in amino acid transamination via a-ketoglutarate and glutamic acid. This amino acid is metabolized by different enzymes, such as glutaminase, present in liver, and glutamine synthetase, present in skeletal muscle. It is produced in the cytoplasm from other amino acids, predominantly from branched-chain amino acids and glutamate. It plays an essential role in ammonia metabolism and detoxification. Its skeletal muscle levels are significantly reduced post trauma, operation and inflammatory states. It servers as a prognostic marker in fatal sepsis during which its skeletal muscle levels are decreased by 90%.

Other Notes

Unnatural isomer of glutamine

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves