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384R-1

SATB2 (EP281) Rabbit Monoclonal Primary Antibody

Name: SATB2 (EP281) Rabbit Monoclonal Primary Antibody
Brand: SIGMA

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About This Item

UNSPSC Code:

12352203

NACRES:

NA.41

biological source

rabbit

Quality Level

100
500

conjugate

unconjugated

antibody form

culture supernatant

antibody product type

primary antibodies

clone

EP281, monoclonal

description

(For In Vitro Diagnostic Use in Select Regions (See Chart))

form

buffered aqueous solution

species reactivity

human

packaging

vial of 0.1 mL concentrate (384R-14)
vial of 0.5 mL concentrate (384R-15)
bottle of 1.0 mL predilute (384R-17)
vial of 1.0 mL concentrate (384R-16)
bottle of 7.0 mL predilute (384R-18)

manufacturer/tradename

Cell Marque^™

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:25-1:100

isotype

IgG

control

colon adenocarcinoma

shipped in

wet ice

storage temp.

2-8°C

visualization

nuclear

Gene Information

human ... SATB2(23314)

Related Categories

Cell Marque

Cell Marque™ Primary Antibodies

Clinical & Diagnostics

General description

Special AT-rich sequence-binding protein 2 (SATB2) is a marker that functions as a nuclear matrix-associated transcription factor that has been shown to identify colorectal carcinomas, including poorly differentiated colorectal carcinomas and metastases. Adenocarcinomasincluding breast, lung, and ovary may express SATB2 at lower frequencies.1 Therefore, SATB2 is useful for identifying a carcinoma of colorectal origin when identifying a cancer of unknown primary.

Quality

IVD

RUO

Linkage

SATB2 Positive Control Slides, Product No. 384S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.

Preparation Note

Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.

Other Notes

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Legal Information

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany

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Cadherin-17 and SATB2 are sensitive and specific immunomarkers for medullary carcinoma of the large intestine.

Fan Lin et al.

Archives of pathology & laboratory medicine, 138(8), 1015-1026 (2014-01-21)

Distinction of medullary carcinoma of the large intestine from other cytokeratin (CK) 7⁻/CK20⁻ carcinomas can be challenging when working on a tumor of unknown primary because the majority of medullary carcinomas are negative for CK7, CK20, and CDX2. To investigate

SATB2 Expression Distinguishes Ovarian Metastases of Colorectal and Appendiceal Origin From Primary Ovarian Tumors of Mucinous or Endometrioid Type.

Michelle Moh et al.

The American journal of surgical pathology, 40(3), 419-432 (2015-11-10)

The primary origin of some ovarian mucinous tumors may be challenging to determine, because some metastases of extraovarian origin may exhibit gross, microscopic, and immunohistochemical features that are shared by some primary ovarian mucinous tumors. Metastases of primary colorectal, appendiceal

SATB2 is a Promising Biomarker for Identifying a Colorectal Origin for Liver Metastatic Adenocarcinomas.

Yi-Jun Zhang et al.

EBioMedicine, 28, 62-69 (2018-02-06)

SATB2 (Special AT-rich sequence-binding protein 2) has recently been shown to be a specific biomarker of colorectal cancer (CRC). The aim of this study was to investigate the diagnostic potential of SATB2 as a means of detecting a CRC origin

SATB2 in combination with cytokeratin 20 identifies over 95% of all colorectal carcinomas.

Kristina Magnusson et al.

The American journal of surgical pathology, 35(7), 937-948 (2011-06-17)

The special AT-rich sequence-binding protein 2 (SATB2), a nuclear matrix-associated transcription factor and epigenetic regulator, was identified as a tissue type-specific protein when screening protein expression patterns in human normal and cancer tissues using an antibody-based proteomics approach. In this

Articles

Immunohistochemistry Applications in Gastrointestinal Cancer

Colorectal cancer is the third most common cancer in both men and women. An estimated 136,000 cases of colorectal cancer are expected to occur in 2016.