850376P

18:1 (Δ9-Trans) PC

1,2-dielaidoyl-sn-glycero-3-phosphocholine, powder

• Synonym(s): 1,2-di-(9E-octadecenoyl)-sn-glycero-3-phosphocholine; PC(18:1(9E)/18:1(9E))
• Empirical Formula (Hill Notation): C₄₄H₈₄NO₈P
• CAS Number: 56782-46-8
• Molecular Weight: 786.11
• UNSPSC Code: 51191904
• NACRES: NA.25

Properties

• Assay: >99% (TLC)
• form: powder
• packaging: pkg of 2 × 100 mg (850376P-200mg); pkg of 1 × 25 mg (850376P-25mg)
• manufacturer/tradename: Avanti Research^™ - A Croda Brand 850376P
• lipid type: phospholipids; cardiolipins
• shipped in: dry ice
• storage temp.: −20°C
• SMILES string: [O-]P(OCC[N+](C)(C)C)(OC[C@]([H])(OC(CCCCCCC/C=C/CCCCCCCC)=O)COC(CCCCCCC/C=C/CCCCCCCC)=O)=O
• InChI: 1S/C44H84NO8P/c1-6-8-10-12-14-16-18-20-22-24-26-28-30-32-34-36-43(46)50-40-42(41-52-54(48,49)51-39-38-45(3,4)5)53-44(47)37-35-33-31-29-27-25-23-21-19-17-15-13-11-9-7-2/h20-23,42H,6-19,24-41H2,1-5H3/b22-20+,23-21+
• InChI key: SNKAWJBJQDLSFF-DQPVQCHKSA-N

Description

General description

18:1 (Δ9-Trans) PC (1,2-dielaidoyl-sn-glycero-3-phosphocholine) is a lipid derivative having a phosphocholine backbone. It also has two 18 carbon fatty acid chains, each having one trans double bond at the 9th carbon. It is an isomeric glycerophosphocholine.

The list of Phosphatidylcholine products offered by Avanti is designed to provide compounds having a variety of physical properties. Products available include short chain (C3-C8 are water soluble and hygroscopic), saturated, multi-unsaturated and mixed acid PC′s. All of the products are purified by HPLC, and special precautions are taken to protect the products for oxidization and hydrolysis.

Application

18:1 (Δ9-Trans) PC (1,2-dielaidoyl-sn-glycero-3-phosphocholine) may be used:

• in the preparation of liposomes/vesicles to examine peptide-mediated leakage
• as a standard phospholipid and a model compound to study the effect of several matrix-assisted laser desorption/ionization (MALDI) matrixes on the degree of the fragmentation of different phospholipids
• as a phosphatidylcholine standard to demonstrate the analytical utility of performing ozonolysis (LC-Oz-IM-MS)

Biochem/physiol Actions

18:1 (Δ9-Trans) PC (1,2-dielaidoyl-sn-glycero-3-phosphocholine) can help paclitaxel in forming thermodynamically stable systems. It has efficient drug penetration ability into the lipid monolayers when compared to other lipids.

Packaging

5 mL Clear Glass Sealed Ampule (850376P-200mg)

5 mL Clear Glass Sealed Ampule (850376P-25mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H315,H319,H335
• Precautionary Statements: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Target Organs: Respiratory system
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable