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Supelco

Calcium ionophore I

Selectophore™, function tested, ≥99.0%

Synonym(s):

(−)-(R,R)-N,N′-Bis-[11-(ethoxycarbonyl)undecyl]-N,N′,4,5-tetramethyl-3,6-dioxaoctane-diamide, Diethyl N,N′-[(4R,5R)-4,5-dimethyl-1,8-dioxo-3,6-dioxaoctamethylene]bis(12-methylaminododecanoate), ETH 1001

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About This Item

Empirical Formula (Hill Notation):
C38H72N2O8
CAS Number:
58801-34-6
Molecular Weight:
684.99
Beilstein:
2343275
EC Number:
261-449-8
MDL number:
MFCD00042943
UNSPSC Code:
26111700
PubChem Substance ID:
329752115
NACRES:
NB.61

grade

for ion-selective electrodes

Quality Level

200

product line

Selectophore™

Assay

≥99.0% (HPLC)
≥99.0%

quality

function tested

SMILES string

CCOC(=O)CCCCCCCCCCCN(C)C(=O)CO[C@H](C)[C@@H](C)OCC(=O)N(C)CCCCCCCCCCCC(=O)OCC

InChI

1S/C38H72N2O8/c1-7-45-37(43)27-23-19-15-11-9-13-17-21-25-29-39(5)35(41)31-47-33(3)34(4)48-32-36(42)40(6)30-26-22-18-14-10-12-16-20-24-28-38(44)46-8-2/h33-34H,7-32H2,1-6H3/t33-,34-/m1/s1

InChI key

CJAONIOAQZUHPN-KKLWWLSJSA-N

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General description

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Application

Selected application examples
Calcium ionophore I (ETH 1001) was used in an experimental study, conducted to determine the intracellular and extracellular changes of calcium ions in hypoxia and ischemia in rat brain.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Other Notes

Used as ionophore in membrane electrodes for the determination of Ca2+-activities; Useful for transport studies in biological membranes

Legal Information

Selectophore is a trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

10 - Combustible liquids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
BCCH1971
BCCB0901
BCCB8340
BCBT7168
BCBT3590

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W. Simon et al.
Annals of the New York Academy of Sciences, 307, 52-52 (1978)
I A Silver et al.
The Journal of general physiology, 95(5), 837-866 (1990-05-01)
Changes in intra- and extracellular free calcium concentration were evaluated with ion-selective microelectrodes during periods of anoxia and ischemia in three different regions of intact rat brain. Recordings stable for at least 2 min and in most cases for 4-6
Rita I Jabr et al.
Pflugers Archiv : European journal of physiology, 468(11-12), 1945-1955 (2016-10-21)
Cardiac arrhythmias are associated with raised intracellular [Ca2+] and slowed action potential conduction caused by reduced gap junction (GJ) electrical conductance (Gj). Ventricular GJs are composed of connexin proteins (Cx43), with Gj determined by Cx43 phosphorylation status. Connexin phosphorylation is
P Caroni et al.
Biochimica et biophysica acta, 470(3), 437-445 (1977-11-01)
The effect of a synthetic neutral ligand on the Ca2+ permeability of several biological membranes has been investigated. The ligand had been previously shown to possess Ca2+ -ionophoric activities in artificial phospholipid membranes. The neutral ionophore is able to transport
N Abuaf et al.
Journal of allergy, 2012, 580873-580873 (2011-12-22)
Background. An in vitro basophil activation test, based on the detection of CD63 upregulation induced by NSAIDs, has been described. Its clinical significance remains controversial. Objectives. In patients with a history of nonallergic NSAID hypersensitivity, stratified according to the severity
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