PARN
poly(A)-specific ribonuclease
Synonyms:
DAN
Species:
Human PARN (5073), Mouse Parn (74108), Rat Parn (360464), sheep PARN (101112185), naked mole-rat Parn (101715275), Domestic Rabbit PARN (100351489), domestic guinea pig Parn (100732149), Zebrafish parn (791461), cow PARN (524155), chicken PARN (416423) ...More
UniProtKB ID:
Gene ID:
- Human(5073) Summary: The protein encoded by this gene is a 3'-exoribonuclease, with similarity to the RNase D family of 3'-exonucleases. It prefers poly(A) as the substrate, hence, efficiently degrades poly(A) tails of mRNAs. Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs. This protein is also involved in silencing of certain maternal mRNAs during oocyte maturation and early embryonic development, as well as in nonsense-mediated decay (NMD) of mRNAs that contain premature stop codons. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]
- Mouse(74108) poly(A)-specific ribonuclease (deadenylation nuclease)
- Rat(360464) poly(A)-specific ribonuclease
- sheep(101112185) poly(A)-specific ribonuclease
- naked mole-rat(101715275) poly(A)-specific ribonuclease
- Domestic Rabbit(100351489) poly(A)-specific ribonuclease
- domestic guinea pig(100732149) poly(A)-specific ribonuclease
- Zebrafish(791461) poly(A)-specific ribonuclease (deadenylation nuclease)
- cow(524155) poly(A)-specific ribonuclease
- chicken(416423) poly(A)-specific ribonuclease
- domestic cat(101100021) poly(A)-specific ribonuclease
- dog(479839) poly(A)-specific ribonuclease
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-PARN antibody produced in rabbit, Ab1, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human, mouse, rat
Application
immunohistochemistry
western blot
western blot
Anti-PARN antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human, mouse, rat
Application
immunohistochemistry
western blot
western blot
Anti-PARN antibody produced in rabbit, IgG fraction of antiserum,
Species Reactivity
bovine, dog, guinea pig, horse, human, mouse, rabbit, rat
Application
western blot
Anti-PARN antibody produced in mouse, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human, mouse, rat
Application
immunofluorescence
western blot
western blot