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Merck

MAPKAPK2

mitogen-activated protein kinase-activated protein kinase 2

Synonyms:
MAPKAP-K2, MK-2, MK2
Species:
UniProtKB ID:
Gene ID:
  • Human(9261) Summary: This gene encodes a member of the Ser/Thr protein kinase family. This kinase is regulated through direct phosphorylation by p38 MAP kinase. In conjunction with p38 MAP kinase, this kinase is known to be involved in many cellular processes including stress and inflammatory responses, nuclear export, gene expression regulation and cell proliferation. Heat shock protein HSP27 was shown to be one of the substrates of this kinase in vivo. Two transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
  • Mouse(17164) MAP kinase-activated protein kinase 2
  • Rat(289014) mitogen-activated protein kinase-activated protein kinase 2
  • chicken(419847) mitogen-activated protein kinase-activated protein kinase 2
  • cow(788091) mitogen-activated protein kinase-activated protein kinase 2
  • dog(490263) mitogen-activated protein kinase-activated protein kinase 2
  • domestic cat(101090833) mitogen-activated protein kinase-activated protein kinase 2
  • naked mole-rat(101708612) mitogen-activated protein kinase-activated protein kinase 2
  • Domestic Rabbit(100009438) mitogen-activated protein kinase-activated protein kinase 2
  • domestic guinea pig(100715906) mitogen-activated protein kinase-activated protein kinase 2
  • sheep(101118118) mitogen-activated protein kinase-activated protein kinase 2

Custom & Knockdown Gene Products

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Antibodies

Product Number
Description
Species Reactivity
Application
Anti-phospho-MAPKAPK2 (pThr334) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
ELISA
immunohistochemistry

western blot
Anti-MAPKAPK-2 Antibody, clone 1E16 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Species Reactivity
bovine, feline, horse, human, monkey, mouse, porcine, rat
Application
affinity binding assay
immunocytochemistry

immunohistochemistry

western blot
Anti-Phospho-MAPKAPK2-T334 antibody produced in rabbit, ,
Species Reactivity
human, mouse, rat
Application
western blot
Anti-MAPKAP-K2 Antibody, clone 7H4.2, clone 7H4.2, Upstate®, from mouse,
Species Reactivity
human, mouse, rat
Application
immunoprecipitation (IP)
western blot
Anti-MAPKAPK2 (Ab-334) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
immunofluorescence
western blot

Small Molecule - Inhibitor

Product Number
Description
Species
Adenine, BioReagent, suitable for cell culture,
Species
human, rat, mouse
Adenine, BioReagent, suitable for plant cell culture, ≥99%,
Species
human, rat, mouse
Adenine, ≥99%,
Species
human, rat, mouse

Proteins

Product Number
Description
Species
MAPKAPK2 human, recombinant, expressed in HEK 293 cells, ≥60 units/mg protein, buffered aqueous glycerol solution,
Species
human
MAPKAP Kinase 2 Protein, active, 10 µg, Active, for use in Kinase Assays.,
Species
human

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting human MAPKAPK2,
Species
human
MISSION® esiRNA, targeting mouse Mapkapk2,
Species
mouse