- Selective [3 + 2] Huisgen cycloaddition. Synthesis of trans-disubstituted triazolodiazepines from aza-Baylis-Hillman adducts.
Selective [3 + 2] Huisgen cycloaddition. Synthesis of trans-disubstituted triazolodiazepines from aza-Baylis-Hillman adducts.
The Journal of organic chemistry (2009-02-10)
Valérie Declerck, Loic Toupet, Jean Martinez, Frédéric Lamaty
PMID19199794
ABSTRACT
The 1,3-dipolar cycloaddition of linear azido alkynes derived from protected beta-amino esters proceeds via diastereomeric differentiation to provide trans-disubstituted triazolodiazepines in good yields.
MATERIALS