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  • Water-soluble pH-responsive dendritic core-shell nanocarriers for polar dyes based on poly(ethylene imine).

Water-soluble pH-responsive dendritic core-shell nanocarriers for polar dyes based on poly(ethylene imine).

Macromolecular bioscience (2007-08-01)
Shangjie Xu, Ying Luo, Rainer Haag
ABSTRACT

A simple general synthetic concept to build dendritic core-shell architectures with pH-labile linkers based on hyperbranched PEI cores and biocompatible PEG shells is presented. Using these dendritic core-shell architectures as nanocarriers, the encapsulation and transport of polar dyes of different sizes is studied. The results show that the acid-labile nanocarriers exhibit much higher transport capacities for dyes than unfunctionalized hyperbranched PEI. The cleavage of imine bonds and controlled release of the polar dyes revealed that weak acidic condition (pH approximately 5.0) could cleave the imine bonds linker and release the dyes up to five times faster than neutral conditions (pH = 7.4).

MATERIALS
Product Number
Brand
Product Description

Supelco
Thymolphthalein, ACS reagent, indicator (pH 8.8-10.5)
Sigma-Aldrich
Thymolphthalein, ACS reagent, Dye content 95 %
Sigma-Aldrich
Thymol Blue sodium salt, ACS reagent, Dye content 95 %
Sigma-Aldrich
Thymol Blue, ACS reagent