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  • Recent advances of controlled drug delivery using microfluidic platforms.

Recent advances of controlled drug delivery using microfluidic platforms.

Advanced drug delivery reviews (2017-09-19)
Sharma T Sanjay, Wan Zhou, Maowei Dou, Hamed Tavakoli, Lei Ma, Feng Xu, XiuJun Li
ABSTRACT

Conventional systematically-administered drugs distribute evenly throughout the body, get degraded and excreted rapidly while crossing many biological barriers, leaving minimum amounts of the drugs at pathological sites. Controlled drug delivery aims to deliver drugs to the target sites at desired rates and time, thus enhancing the drug efficacy, pharmacokinetics, and bioavailability while maintaining minimal side effects. Due to a number of unique advantages of the recent microfluidic lab-on-a-chip technology, microfluidic lab-on-a-chip has provided unprecedented opportunities for controlled drug delivery. Drugs can be efficiently delivered to the target sites at desired rates in a well-controlled manner by microfluidic platforms via integration, implantation, localization, automation, and precise control of various microdevice parameters. These features accordingly make reproducible, on-demand, and tunable drug delivery become feasible. On-demand self-tuning dynamic drug delivery systems have shown great potential for personalized drug delivery. This review presents an overview of recent advances in controlled drug delivery using microfluidic platforms. The review first briefly introduces microfabrication techniques of microfluidic platforms, followed by detailed descriptions of numerous microfluidic drug delivery systems that have significantly advanced the field of controlled drug delivery. Those microfluidic systems can be separated into four major categories, namely drug carrier-free micro-reservoir-based drug delivery systems, highly integrated carrier-free microfluidic lab-on-a-chip systems, drug carrier-integrated microfluidic systems, and microneedles. Microneedles can be further categorized into five different types, i.e. solid, porous, hollow, coated, and biodegradable microneedles, for controlled transdermal drug delivery. At the end, we discuss current limitations and future prospects of microfluidic platforms for controlled drug delivery.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Droplet generator chip - Multi channel design, Fluidic 912, PC
Pricing and availability is not currently available.
Sigma-Aldrich
Droplet generation and storage chip, Fluidic 719, PC
Pricing and availability is not currently available.
Sigma-Aldrich
Droplet generator chip - Multi channel design, Fluidic 1032, COC
Pricing and availability is not currently available.
Sigma-Aldrich
Droplet generator chip - One channel design, Fluidic 163, PC
Pricing and availability is not currently available.
Sigma-Aldrich
Droplet generator chip - One channel design, Fluidic 162, PC
Pricing and availability is not currently available.
Sigma-Aldrich
Droplet generation and storage chip, Fluidic 488, PC
Pricing and availability is not currently available.
Sigma-Aldrich
Rhombic chamber chip - 100 μl, Fluidic 221, PMMA
Pricing and availability is not currently available.
Sigma-Aldrich
Reaction chamber chip - 6 μl, Fluidic 132, COP
Pricing and availability is not currently available.
Sigma-Aldrich
Straight channel chip (4 parallel channels), Fluidic 138, PMMA
Pricing and availability is not currently available.
Sigma-Aldrich
Droplet generator chip - One channel design, Fluidic 162, COC
Pricing and availability is not currently available.
Sigma-Aldrich
Droplet generation and storage chip, Fluidic 488, COC
Pricing and availability is not currently available.
Sigma-Aldrich
Droplet generator chip - Multi channel design, Fluidic 440, COC
Pricing and availability is not currently available.
Sigma-Aldrich
Droplet generator chip - One channel design, Fluidic 163, COC
Pricing and availability is not currently available.
Sigma-Aldrich
Droplet generation and storage chip, Fluidic 719, COC
Pricing and availability is not currently available.
Sigma-Aldrich
Droplet generator chip - Multi channel design, Fluidic 440, PC
Pricing and availability is not currently available.
Sigma-Aldrich
Droplet generator chip - Multi channel design, Fluidic 1032, PC
Pricing and availability is not currently available.
Sigma-Aldrich
Male Mini Luer fluid connector, single, Fluidic 331, PP
Pricing and availability is not currently available.
Sigma-Aldrich
Droplet generator chip - Multi channel design, Fluidic 912, COC
Pricing and availability is not currently available.
Sigma-Aldrich
Droplet generator chip - Multi channel design, Fluidic 285, PC
Pricing and availability is not currently available.
Sigma-Aldrich
Straight channel chip (4 parallel channels), Fluidic 156, PMMA
Pricing and availability is not currently available.
Sigma-Aldrich
200 μl tank with Mini Luer interface, Fluidic 926, PP
Pricing and availability is not currently available.
Sigma-Aldrich
Male mini luer plug, single, Fluidic 334, PP
Pricing and availability is not currently available.
Sigma-Aldrich
Reaction chamber chip - various volume chambers, Fluidic 620, COC
Pricing and availability is not currently available.
Sigma-Aldrich
Male mini luer plug, single, Fluidic 334, TPE
Pricing and availability is not currently available.
Sigma-Aldrich
3D-Serpentine Mixer, Fluidic 1079, PC
Pricing and availability is not currently available.
Sigma-Aldrich
Spiral sorter, Fluidic 382, COP
Pricing and availability is not currently available.
Sigma-Aldrich
Various Height Reaction Chamber Chip, Fluidic 1100 PS
Pricing and availability is not currently available.
Sigma-Aldrich
Various Height Reaction Chamber Chip, Fluidic 1099 PS
Pricing and availability is not currently available.
Sigma-Aldrich
Pearl-chain mixer, Fluidic 658, PC
Pricing and availability is not currently available.
Sigma-Aldrich
Spiral sorter, Fluidic 382, PMMA
Pricing and availability is not currently available.