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Z-013

Supelco

Zopiclone-N-oxide solution

100 μg/mL (Methanol with 1% 1 M HCl), ampule of 1 mL, certified reference material, Cerilliant®

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About This Item

Empirical Formula (Hill Notation):
C17H17ClN6O4
CAS Number:
43200-96-0
Molecular Weight:
404.81
MDL number:
MFCD00871938
UNSPSC Code:
41116107
PubChem Substance ID:
329831596
NACRES:
NA.24

grade

certified reference material

Quality Level

300

form

liquid

feature

(Snap-N-Spike®)

packaging

ampule of 1 mL

manufacturer/tradename

Cerilliant®

concentration

100 μg/mL (Methanol with 1% 1 M HCl)

technique(s)

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

application(s)

clinical testing

format

single component solution

storage temp.

−20°C

SMILES string

O=C1N(C2=CC=C(Cl)C=N2)C(OC(N3CC[N+]([O-])(C)CC3)=O)C4=C1N=CC=N4

InChI

1S/C17H17ClN6O4/c1-24(27)8-6-22(7-9-24)17(26)28-16-14-13(19-4-5-20-14)15(25)23(16)12-3-2-11(18)10-21-12/h2-5,10,16H,6-9H2,1H3

InChI key

IPTIKKTXLHVRKN-UHFFFAOYSA-N

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General description

Zopiclone N-oxide is a primary, active metabolite of zopiclone in urine as well as a major pharmaceutical impurity of zopiclone known as eszopiclone impurity A. The parent drug, zopiclone, is a non-benzodiazepine hypnotic sold under the trade names Imovane®and ZImovane®and is used in the treatment of insomnia.

Application


  • Enantioselective analysis of zopiclone and its metabolites: A study developed a DLLME-CE method for the enantioselective analysis of zopiclone and its active metabolite, zopiclone-N-oxide, post fungal biotransformation, demonstrating the utility of zopiclone-N-oxide as a reference standard in pharmaceutical metabolite profiling (de Albuquerque et al., 2015).

  • Pharmacokinetic studies: An analytical method using liquid chromatography/tandem mass spectrometry was employed for the enantioselective analysis of zopiclone and its metabolites in plasma, showcasing zopiclone-N-oxide′s critical role in bioanalytical studies related to insomnia and GABA receptor modulation (Tonon et al., 2011).


Legal Information

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Imovane is a registered trademark of Sanofi-Aventis
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

Signal Word

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

Storage Class Code

3 - Flammable liquids

WGK

WGK 2

Flash Point(F)

49.5 °F - closed cup

Flash Point(C)

9.7 °C - closed cup

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

EU REACH Annex XVII (Restriction List)

CAS No.

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Articles

HPLC Analysis of Z-Drugs on Ascentis® Express ES-Cyano 2.0 μm

An rapid method for the siµLtaneous determination of the Z-drugs or sleep aids: zopiclone, zolpidem, and zaleplon is presented here. The need for greater analytical capacity and throughput for the analysis of sleep aid medicines (Z-drugs) in forensic toxicology laboratories can be met by the use of fast Ascentis Express 2.0 micron Fused Core UHPLC Columns.

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