XIAP
X-linked inhibitor of apoptosis
Synonyms:
API3, BIRC4, IAP-3, ILP1, MIHA, XLP2, hIAP-3, hIAP3
Species:
Human XIAP (331), Mouse Xiap (11798), Rat Xiap (63879), Zebrafish xiap (373108), domestic cat XIAP (101090594), Horse XIAP (100060870), dog XIAP (442989), chicken XIAP (395280), domestic guinea pig Xiap (100715778), naked mole-rat Xiap (101715865) ...More
UniProtKB ID:
Gene ID:
- Human(331) Summary: This gene encodes a protein that belongs to a family of apoptotic suppressor proteins. Members of this family share a conserved motif termed, baculovirus IAP repeat, which is necessary for their anti-apoptotic function. This protein functions through binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2 and inhibits apoptosis induced by menadione, a potent inducer of free radicals, and interleukin 1-beta converting enzyme. This protein also inhibits at least two members of the caspase family of cell-death proteases, caspase-3 and caspase-7. Mutations in this gene are the cause of X-linked lymphoproliferative syndrome. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 2 and 11.[provided by RefSeq, Feb 2011]
- Mouse(11798) X-linked inhibitor of apoptosis
- Rat(63879) X-linked inhibitor of apoptosis
- Zebrafish(373108) X-linked inhibitor of apoptosis
- domestic cat(101090594) X-linked inhibitor of apoptosis
- Horse(100060870) X-linked inhibitor of apoptosis
- dog(442989) X-linked inhibitor of apoptosis
- chicken(395280) X-linked inhibitor of apoptosis
- domestic guinea pig(100715778) X-linked inhibitor of apoptosis
- naked mole-rat(101715865) X-linked inhibitor of apoptosis
- Domestic Rabbit(100328700) X-linked inhibitor of apoptosis
- cow(281647) X-linked inhibitor of apoptosis
- sheep(101116381) X-linked inhibitor of apoptosis
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ELISA
Small Molecule - Antagonist
Product Number
Description
Species
Antibodies
Product Number
Description
Species Reactivity
Application
Anti-BIRC4 antibody produced in mouse, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
western blot
Anti-XIAP antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution,
Species Reactivity
human, mouse
Application
ELISA
immunofluorescence
immunohistochemistry
western blot
immunofluorescence
immunohistochemistry
western blot
Anti-phospho-XIAP (pSer87) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
ELISA
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-phospho-XIAP (pSer87) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human
Application
western blot
Monoclonal Anti-BIRC4 antibody produced in mouse, clone 1F4, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
immunofluorescence
proximity ligation assay
western blot
immunofluorescence
proximity ligation assay
western blot
Proteins
Product Number
Description
Species
XIAP, GST tagged human, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution,
Species
human
XIAP Active human, recombinant, expressed in baculovirus infected insect cells, ≥65% (SDS-PAGE),
Species
human