DAG1
dystroglycan 1 (dystrophin-associated glycoprotein 1)
Synonyms:
156DAG, A3a, AGRNR, DAG, MDDGC7, MDDGC9
Species:
Human DAG1 (1605), Mouse Dag1 (13138), Rat Dag1 (114489), sheep DAG1 (101103515), Domestic Rabbit DAG1 (100009278), naked mole-rat Dag1 (101714190), domestic guinea pig Dag1 (100734382), Zebrafish dag1 (286829), cow DAG1 (281439), Horse DAG1 (100053150) ...More
UniProtKB ID:
Gene ID:
- Human(1605) Summary: Dystroglycan is a laminin binding component of the dystrophin-glycoprotein complex which provides a linkage between the subsarcolemmal cytoskeleton and the extracellular matrix. Dystroglycan 1 is a candidate gene for the site of the mutation in autosomal recessive muscular dystrophies. The dramatic reduction of dystroglycan 1 in Duchenne muscular dystrophy leads to a loss of linkage between the sarcolemma and extracellular matrix, rendering muscle fibers more susceptible to necrosis. Dystroglycan also functions as dual receptor for agrin and laminin-2 in the Schwann cell membrane. The muscle and nonmuscle isoforms of dystroglycan differ by carbohydrate moieties but not protein sequence. Alternative splicing results in multiple transcript variants all encoding the same protein.[provided by RefSeq, Apr 2010]
- Mouse(13138) dystroglycan 1
- Rat(114489) dystroglycan 1 (dystrophin-associated glycoprotein 1)
- sheep(101103515) dystroglycan 1 (dystrophin-associated glycoprotein 1)
- Domestic Rabbit(100009278) dystroglycan 1 (dystrophin-associated glycoprotein 1)
- naked mole-rat(101714190) dystroglycan 1 (dystrophin-associated glycoprotein 1)
- domestic guinea pig(100734382) dystroglycan 1 (dystrophin-associated glycoprotein 1)
- Zebrafish(286829) dystroglycan 1
- cow(281439) dystroglycan 1 (dystrophin-associated glycoprotein 1)
- Horse(100053150) dystroglycan 1 (dystrophin-associated glycoprotein 1)
- domestic cat(100174781) dystroglycan 1 (dystrophin-associated glycoprotein 1)
- dog(476623) dystroglycan 1 (dystrophin-associated glycoprotein 1)
- chicken(100049058) dystroglycan 1 (dystrophin-associated glycoprotein 1)
- Thale Cress(825358) Dof zinc finger protein DOF3.7
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-Cranin Antibody, aa572-604 of human sequence, clone 6C1, ascites fluid, clone 6C1, Chemicon®,
Species Reactivity
xenopus, chicken, human, mouse, rat, sheep
Application
ELISA
immunocytochemistry
immunohistochemistry
immunocytochemistry
immunohistochemistry
Anti-α-Dystroglycan Antibody, ,
Species Reactivity
canine, guinea pig, human, mouse, rabbit, rat
Application
Anti-α-Dystroglycan Antibody, clone VIA4-1, culture supernatant, clone VIA4-1, Upstate®,
Species Reactivity
canine, guinea pig, human, mouse, rabbit, rat
Application
immunohistochemistry
western blot
western blot
Anti-DAG1 antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
bovine, canine, guinea pig, horse, human, mouse, pig, rabbit, zebrafish
Application
immunohistochemistry
western blot
western blot
Anti-DAG1 antibody produced in rabbit biotin conjugted, affinity isolated antibody,
Species Reactivity
bovine, canine, guinea pig, horse, human, mouse, pig, rabbit, zebrafish
Application
immunohistochemistry