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  • Linoleic acid participates in the response to ischemic brain injury through oxidized metabolites that regulate neurotransmission.

Linoleic acid participates in the response to ischemic brain injury through oxidized metabolites that regulate neurotransmission.

Scientific reports (2017-07-01)
Marie Hennebelle, Zhichao Zhang, Adam H Metherel, Alex P Kitson, Yurika Otoki, Christine E Richardson, Jun Yang, Kin Sing Stephen Lee, Bruce D Hammock, Liang Zhang, Richard P Bazinet, Ameer Y Taha
PMID28659576
ABSTRACT

Linoleic acid (LA; 18:2 n-6), the most abundant polyunsaturated fatty acid in the US diet, is a precursor to oxidized metabolites that have unknown roles in the brain. Here, we show that oxidized LA-derived metabolites accumulate in several rat brain regions during CO