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  • A bidirectional synthesis of spiroacetals via Rh(ii)-catalysed C-H insertion.

A bidirectional synthesis of spiroacetals via Rh(ii)-catalysed C-H insertion.

Chemical communications (Cambridge, England) (2017-03-31)
Romain J Lepage, Jonathan M White, Mark J Coster
PMID28357432
ABSTRACT

Acyclic methylene acetals bearing two diazoester subunits have been converted to [5,5]-spiroacetals via bidirectional C-H insertion under Rh(ii) catalysis. Using a chiral Rh(ii) catalyst, the major diastereomer can be produced in high enantiomeric excess (89%).