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1432005

USP

Methylparaben

United States Pharmacopeia (USP) Reference Standard

Synonym(s):

Methyl 4-hydroxybenzoate, p-Hydroxybenzoic acid methyl ester, Methyl paraben, NIPAGIN

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About This Item

Linear Formula:
HOC6H4CO2CH3
CAS Number:
99-76-3
Molecular Weight:
152.15
Beilstein:
509801
MDL number:
MFCD00002352
UNSPSC Code:
41116107
PubChem Substance ID:
329750452
NACRES:
NA.24

grade

pharmaceutical primary standard

API family

parabens

manufacturer/tradename

USP

mp

125-128 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

SMILES string

COC(=O)c1ccc(O)cc1

InChI

1S/C8H8O3/c1-11-8(10)6-2-4-7(9)5-3-6/h2-5,9H,1H3

InChI key

LXCFILQKKLGQFO-UHFFFAOYSA-N

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General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Methylparaben USP reference standard for specified quality tests and assay use only.

Also used to prepare the standard, standard stock, system suitability, and system suitability stock solutions for assay, identification, and performance test according to the given below monographs of United States Pharmacopeia (USP):
  • Methylparaben
  • Methylparaben Sodium
  • Dexamethasone Oral Solution
  • Ethylparaben Sodium
  • Benzaldehyde

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Other Notes

Sales restrictions may apply.

related product

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PHR1010

Propylparaben, Pharmaceutical Secondary Standard; Certified Reference Material

PHR1011

Ethylparaben, Pharmaceutical Secondary Standard; Certified Reference Material

PHR1022

Butylparaben, Pharmaceutical Secondary Standard; Certified Reference Material

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Butylparaben, United States Pharmacopeia (USP) Reference Standard

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Ethylparaben, United States Pharmacopeia (USP) Reference Standard

1577008

Propylparaben, United States Pharmacopeia (USP) Reference Standard

E2425000

Ethyl parahydroxybenzoate, European Pharmacopoeia (EP) Reference Standard

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P3650000

Propyl parahydroxybenzoate, European Pharmacopoeia (EP) Reference Standard

Pictograms

Environment
GHS09

Hazard Statements

H411

Precautionary Statements

P273 - P391 - P501

Hazard Classifications

Aquatic Chronic 2

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 1

Flash Point(F)

334.4 °F

Flash Point(C)

168 °C

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Journal of chromatographic science, 52(1), 88-94 (2013-01-18)
This paper reports the development of a method for simultaneously determining five preservatives in cosmetics, cleaning agents and pharmaceuticals by fast liquid chromatography. Methylisothiazolinone, methylchloroisothiazolinone, benzyl alcohol, sodium benzoate and methylparaben were separated on a Chromolith Fast Gradient reversed-phase 18e
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Retina (Philadelphia, Pa.), 34(5), 935-942 (2013-10-10)
To determine whether the application of subconjunctival 2% lidocaine/0.1% methylparaben for anesthesia may reduce rates of endophthalmitis after intravitreal (IVT) injection. We performed in vitro experiments to determine the antibacterial properties of 2% lidocaine/0.1% methylparaben (lidocaine) against causative organisms of
M G Soni et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 40(10), 1335-1373 (2002-10-22)
Methyl paraben (CAS No. 99-76-3) is a methyl ester of p-hydroxybenzoic acid. It is a stable, non-volatile compound used as an antimicrobial preservative in foods, drugs and cosmetics for over 50 years. Methyl paraben is readily and completely absorbed through
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PloS one, 9(11), e111215-e111215 (2014-11-12)
Alzheimer's disease (AD) is a progressive neurodegenerative disease that causes substantial public health care burdens. Intensive efforts have been made to find effective and safe disease-modifying treatment and symptomatic intervention alternatives against AD. Smart Soup (SS), a Chinese medicine formula
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Protocols

HPLC Analysis of Paraben Preservatives on Discovery® C18

Separation of Methyl Paraben, analytical standard; Ethylparaben, United States Pharmacopeia (USP) Reference Standard; Propylparaben, United States Pharmacopeia (USP) Reference Standard; Butylparaben, United States Pharmacopeia (USP) Reference Standard

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