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M2199

Sigma-Aldrich

PMEG hydrate

≥98% (HPLC)

Synonym(s):

9-[2-(Phosphonomethoxy)ethyl]guanine hydrate

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About This Item

Empirical Formula (Hill Notation):
C8H12N5O5P · xH2O
CAS Number:
Molecular Weight:
289.19 (anhydrous basis)
MDL number:
UNSPSC Code:
12352202
PubChem Substance ID:
NACRES:
NA.77

Pricing and availability is not currently available.

Quality Level

Assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to off-white

solubility

DMSO: ≥5 mg/mL

storage temp.

2-8°C

SMILES string

O.NC1=Nc2c(ncn2CCOCP(O)(O)=O)C(=O)N1

InChI

1S/C8H12N5O5P.H2O/c9-8-11-6-5(7(14)12-8)10-3-13(6)1-2-18-4-19(15,16)17;/h3H,1-2,4H2,(H2,15,16,17)(H3,9,11,12,14);1H2

InChI key

BDVQXHFCXJXVND-UHFFFAOYSA-N

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This Item
PZ0158D6196SML2774
assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

−20°C

storage condition

desiccated

storage condition

desiccated

storage condition

-

storage condition

desiccated

solubility

DMSO: ≥5 mg/mL

solubility

DMSO: ≥45 mg/mL

solubility

H2O: ≥10 mg/mL

solubility

H2O: 2 mg/mL, clear

Biochem/physiol Actions

The acyclic nucleotide 9-(2-phosphonylmethoxyethyl)guanine (PMEG) forms an active phosphorylated metabolite, PMEG diphosphate (PMEGpp), in cells and causes cytotoxicity in dividing cells due to potent inhibition of the nuclear DNA polymerases resulting in inhibition of DNA synthesis and/or DNA repair.

Pictograms

Skull and crossbones

Signal Word

Danger

Hazard Statements

Hazard Classifications

Acute Tox. 2 Oral

Storage Class Code

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3


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