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I18008

Sigma-Aldrich

Isonipecotic acid

97%

Synonym(s):

4-Piperidinecarboxylic acid, Hexahydroisonicotinic acid

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About This Item

Empirical Formula (Hill Notation):
C6H11NO2
CAS Number:
Molecular Weight:
129.16
Beilstein:
112553
EC Number:
MDL number:
UNSPSC Code:
12352100
PubChem Substance ID:
NACRES:
NA.22

Assay

97%

mp

>300 °C (lit.)

SMILES string

OC(=O)C1CCNCC1

InChI

1S/C6H11NO2/c8-6(9)5-1-3-7-4-2-5/h5,7H,1-4H2,(H,8,9)

InChI key

SRJOCJYGOFTFLH-UHFFFAOYSA-N

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Application

Reactant for synthesis of:
  • Antibiotic nitroxoline derivatives for cathepsin B inhibition
  • Sphingosine-1-phosphate receptor agonists
  • RhoA inhibitors for cardiovascular disease therapy
  • Alkyl piperidine and piperazine hydroxamic acids as HDAC inhibitors
  • CHK1 inhibitors
  • IKK2 inhibitors for investigations into rheumatoid arthritis treatment

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Clinica chimica acta; international journal of clinical chemistry, 440, 108-112 (2014-12-03)
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Bioorganic & medicinal chemistry, 19(21), 6409-6418 (2011-10-01)
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Studies of gene function and molecular mechanisms in Plasmodium falciparum are hampered by difficulties in characterizing and measuring phenotypic differences between individual parasites. We screened seven parasite lines for differences in responses to 1,279 bioactive chemicals. Hundreds of compounds were
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