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Merck

PTBP1

polypyrimidine tract binding protein 1

Synonyms:
HNRNP-I, HNRNPI, HNRPI, PTB, PTB-1, PTB-T, PTB2, PTB3, PTB4, pPTB
Species:
Human PTBP1 (5725), Mouse Ptbp1 (19205), Rat Ptbp1 (29497), chicken PTBP1 (420098), dog PTBP1 (485097), Horse PTBP1 (100061673), domestic cat PTBP1 (101092744), cow PTBP1 (282018), sheep PTBP1 (101115119), domestic guinea pig Ptbp1 (100721462)
UniProtKB ID:
P26599, Q9BUQ0
Gene ID:
  • Human(5725) Summary: This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA-binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has four repeats of quasi-RNA recognition motif (RRM) domains that bind RNAs. This protein binds to the intronic polypyrimidine tracts that requires pre-mRNA splicing and acts via the protein degradation ubiquitin-proteasome pathway. It may also promote the binding of U2 snRNP to pre-mRNAs. This protein is localized in the nucleoplasm and it is also detected in the perinucleolar structure. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
  • Mouse(19205) polypyrimidine tract binding protein 1
  • Rat(29497) polypyrimidine tract binding protein 1
  • chicken(420098) polypyrimidine tract binding protein 1
  • dog(485097) polypyrimidine tract binding protein 1
  • Horse(100061673) polypyrimidine tract binding protein 1
  • domestic cat(101092744) polypyrimidine tract binding protein 1
  • cow(282018) polypyrimidine tract binding protein 1
  • sheep(101115119) polypyrimidine tract binding protein 1
  • domestic guinea pig(100721462) polypyrimidine tract binding protein 1
  • naked mole-rat(101715554) polypyrimidine tract binding protein 1

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Antibodies

Product Number
Description
Species Reactivity
Application
SAB2500834
Anti-PTBP1/PTB antibody produced in goat, affinity isolated antibody, buffered aqueous solution,
Species Reactivity
human, mouse, rat
Application
ELISA
immunohistochemistry
western blot
AV40421
Anti-PTBP1 antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
bovine, guinea pig, horse, human, mouse, rat
Application
western blot
WH0005725M1
Monoclonal Anti-PTBP1 antibody produced in mouse, clone 3H8, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
immunofluorescence
immunohistochemistry
immunoprecipitation (IP)
western blot
SAB4301714
Anti-PTBP1, affinity isolated antibody,
Species Reactivity
human
Application
immunohistochemistry
western blot
MABE986
Anti-PTB Antibody, clone BB7, clone Bb7, from mouse,
Species Reactivity
human, mouse
Application
immunocytochemistry
immunoprecipitation (IP)
western blot

esiRNA

Product Number
Description
Species
EMU219241
MISSION® esiRNA, targeting mouse PTBP1,
Species
mouse
EHU088121
MISSION® esiRNA, targeting human PTBP1,
Species
human