KDELR1
KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1
Synonyms:
ERD2, ERD2.1, HDEL, PM23
Species:
Human KDELR1 (10945), Mouse Kdelr1 (68137), Rat Kdelr1 (361577), dog KDELR1 (484406), cow KDELR1 (618184), domestic cat KDELR1 (101088968), domestic guinea pig Kdelr1 (100733302), naked mole-rat Kdelr1 (101696486)
UniProtKB ID:
Gene ID:
- Human(10945) Summary: Retention of resident soluble proteins in the lumen of the endoplasmic reticulum (ER) is achieved in both yeast and animal cells by their continual retrieval from the cis-Golgi, or a pre-Golgi compartment. Sorting of these proteins is dependent on a C-terminal tetrapeptide signal, usually lys-asp-glu-leu (KDEL) in animal cells, and his-asp-glu-leu (HDEL) in S. cerevisiae. This process is mediated by a receptor that recognizes, and binds the tetrapeptide-containing protein, and returns it to the ER. In yeast, the sorting receptor encoded by a single gene, ERD2, which is a seven-transmembrane protein. Unlike yeast, several human homologs of the ERD2 gene, constituting the KDEL receptor gene family, have been described. The protein encoded by this gene was the first member of the family to be identified, and it encodes a protein structurally and functionally similar to the yeast ERD2 gene product. [provided by RefSeq, Jul 2008]
- Mouse(68137) KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1
- Rat(361577) KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1
- dog(484406) KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1
- cow(618184) KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1
- domestic cat(101088968) KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1
- domestic guinea pig(100733302) KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1
- naked mole-rat(101696486) KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1
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Antibodies
Product Number
Description
Species Reactivity
Application
Monoclonal Anti-KDELR1 antibody produced in mouse, clone KR10, 1 mg/mL, purified immunoglobulin,
Species Reactivity
drosophila, xenopus, bovine, canine, chicken, hamster, human, monkey, mouse, pig, rabbit, rat, sheep
Application
immunocytochemistry
immunohistochemistry
immunoprecipitation (IP)
western blot
immunohistochemistry
immunoprecipitation (IP)
western blot
Anti-KDEL Mouse mAb (10C3), liquid, clone 10C3, Calbiochem®,
Species Reactivity
drosophila, canine, guinea pig, hamster, human, monkey, mouse, porcine, rabbit, rat, sheep, yeast
Application