GREM1
gremlin 1, DAN family BMP antagonist
Synonyms:
CKTSF1B1, DAND2, DRM, GREMLIN, IHG-2
Species:
Human GREM1 (26585), Mouse Grem1 (23892), Rat Grem1 (50566), chicken GREM1 (395826), cow GREM1 (539079), domestic cat GREM1 (101096735), dog GREM1 (487475), Goat GREM1 (100860969), sheep GREM1 (101102396), domestic guinea pig Grem1 (100730568)
UniProtKB ID:
Gene ID:
- Human(26585) Summary: This gene encodes a member of the BMP (bone morphogenic protein) antagonist family. Like BMPs, BMP antagonists contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists, to which this gene belongs, is characterized by a C-terminal cystine knot with an eight-membered ring. The antagonistic effect of the secreted glycosylated protein encoded by this gene is likely due to its direct binding to BMP proteins. As an antagonist of BMP, this gene may play a role in regulating organogenesis, body patterning, and tissue differentiation. In mouse, this protein has been shown to relay the sonic hedgehog (SHH) signal from the polarizing region to the apical ectodermal ridge during limb bud outgrowth. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]
- Mouse(23892) gremlin 1
- Rat(50566) gremlin 1
- chicken(395826) gremlin 1
- cow(539079) gremlin 1
- domestic cat(101096735) gremlin 1
- dog(487475) gremlin 1
- Goat(100860969) gremlin 1
- sheep(101102396) gremlin 1
- domestic guinea pig(100730568) gremlin 1, DAN family BMP antagonist
- naked mole-rat(101720734) gremlin 1, DAN family BMP antagonist
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ELISA
Product Number
Description
Species
Mouse Gremlin-1 ELISA Kit, for cell culture supernatants, plasma, and serum samples,
Species
mouse
Antibodies
Product Number
Description
Species Reactivity
Application
Anti-Grem1 antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
bovine, canine, goat, guinea pig, horse, human, mouse, rabbit, rat, zebrafish
Application
western blot
ANTI-GREMLIN (C-TERM) antibody produced in rabbit, IgG fraction of antiserum, buffered aqueous solution,
Species Reactivity
human, mouse
Application
immunohistochemistry
western blot
western blot
Monoclonal Anti-GREM1 antibody produced in mouse, clone 2C9, ascites fluid, solution,
Species Reactivity
human
Application
ELISA
Anti-Grem1 (C-terminal) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
bovine, canine, goat, guinea pig, horse, human, mouse, rabbit, zebrafish
Application
western blot
Anti-Grem1 (C-terminal) antibody produced in rabbit FITC conjugated, affinity isolated antibody,
Species Reactivity
bovine, canine, goat, guinea pig, horse, human, mouse, rabbit, zebrafish
Application
Proteins
Product Number
Description
Species
GREMLIN-1 human, recombinant, expressed in CHO cells, ≥90% (SDS-PAGE), ≥90% (HPLC),
Species
human