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Merck

GABRG3

gamma-aminobutyric acid (GABA) A receptor, gamma 3

Synonyms:
Species:
UniProtKB ID:
Gene ID:
  • Human(2567) Summary: This gene encodes a gamma-aminobutyric acid (GABA) receptor. GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. GABA-A receptors are pentameric, consisting of proteins from several subunit classes: alpha, beta, gamma, delta and rho. The protein encoded by this gene is a gamma subunit, which contains the benzodiazepine binding site. Two transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Aug 2012]
  • Mouse(14407) gamma-aminobutyric acid (GABA) A receptor, subunit gamma 3
  • Rat(79211) gamma-aminobutyric acid (GABA) A receptor, gamma 3
  • domestic guinea pig(100729690) gamma-aminobutyric acid (GABA) A receptor, gamma 3
  • naked mole-rat(101712623) gamma-aminobutyric acid (GABA) A receptor, gamma 3
  • sheep(101108521) gamma-aminobutyric acid (GABA) A receptor, gamma 3
  • Zebrafish(567057) gamma-aminobutyric acid (GABA) A receptor, gamma 3
  • cow(613670) gamma-aminobutyric acid (GABA) A receptor, gamma 3
  • domestic cat(101094182) gamma-aminobutyric acid (GABA) A receptor, gamma 3
  • dog(488685) gamma-aminobutyric acid (GABA) A receptor, gamma 3
  • chicken(770097) gamma-aminobutyric acid (GABA) A receptor, gamma 3

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Small Molecule - Agonist

Product Number
Description
Species
2-Bromo-2-chloro-1,1,1-trifluoroethane, ≥99%,
Species
human

Small Molecule - Allosteric Modulator

Product Number
Description
Species
Oxazepam for peak identification, European Pharmacopoeia (EP) Reference Standard,
Species
human
Flunitrazepam, British Pharmacopoeia (BP) Reference Standard,
Species
human
Flurazepam-D4 solution, 100 μg/mL in methanol, certified reference material, Cerilliant®,
Species
human
Etomidate, >98% (HPLC), powder,
Species
human
Clonazepam, British Pharmacopoeia (BP) Reference Standard,
Species
human

Small Molecule - Antagonist

Product Number
Description
Species
Ganaxolone, ≥98% (HPLC), solid,
Species
human, mouse
Flunitrazepam, ,
Species
human
Flumazenil, >99% (HPLC), solid,
Species
rat, human
5α-Pregnan-3α-ol-20-one, solid,
Species
human, mouse, rat
Acamprosate calcium, British Pharmacopoeia (BP) Reference Standard,
Species
human

Antibodies

Product Number
Description
Species Reactivity
Application
Anti-GABRG3 antibody produced in rabbit, IgG fraction of antiserum,
Species Reactivity
human
Application
western blot
Anti-GABRG3 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunohistochemistry

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting human GABRG3,
Species
human