CDK4
cyclin-dependent kinase 4
Synonyms:
CMM3, PSK-J3
Species:
Human CDK4 (1019), Mouse Cdk4 (12567), Rat Cdk4 (94201), naked mole-rat Cdk4 (101702608), domestic guinea pig Cdk4 (100717960), sheep CDK4 (100144756), Domestic Rabbit CDK4 (100009039), Zebrafish cdk4 (777730), fruit fly Cdk4 (36854), cow CDK4 (510618) ...More
UniProtKB ID:
Gene ID:
- Human(1019) Summary: The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb). Mutations in this gene as well as in its related proteins including D-type cyclins, p16(INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. Multiple polyadenylation sites of this gene have been reported. [provided by RefSeq, Jul 2008]
- Mouse(12567) cyclin-dependent kinase 4
- Rat(94201) cyclin-dependent kinase 4
- naked mole-rat(101702608) cyclin-dependent kinase 4
- domestic guinea pig(100717960) cyclin-dependent kinase 4
- sheep(100144756) cyclin-dependent kinase 4
- Domestic Rabbit(100009039) cyclin-dependent kinase 4
- Zebrafish(777730) cyclin-dependent kinase 4
- fruit fly(36854) Cyclin-dependent kinase 4
- cow(510618) cyclin-dependent kinase 4
- domestic cat(101097903) cyclin-dependent kinase 4
- dog(481131) cyclin-dependent kinase 4
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Antibodies
Product Number
Description
Species Reactivity
Application
Monoclonal Anti-CDK4 antibody produced in mouse, clone 4F11, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human, mouse, rat
Application
ELISA
immunofluorescence
western blot
immunofluorescence
western blot
Anti-CDK4 (AB1) antibody produced in rabbit, IgG fraction of antiserum,
Species Reactivity
human
Application
western blot
Monoclonal Anti-CDK4 antibody produced in mouse, Prestige Antibodies® Powered by Atlas Antibodies, clone CL8102, purified immunoglobulin, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunofluorescence
immunohistochemistry
immunohistochemistry
Anti-Phospho-CDK4-T172 antibody produced in rabbit, ,
Species Reactivity
human, mouse, rat
Application
western blot
Anti-CDK4 (C-terminal) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
bovine, canine, guinea pig, horse, human, pig, rabbit, rat
Application
immunohistochemistry
western blot
western blot
Small Molecule - Inhibitor
Product Number
Description
Species
Proteins
Product Number
Description
Species
CDK4/Cyclin D1 active human, recombinant, expressed in baculovirus infected Sf9 cells, ≥90% (SDS-PAGE),
Species
human
CDK4/CyclinD3, active, GST tagged human, PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution,
Species
human
CDK4/Cyclin D1, active, GST tagged human, PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution,
Species
human