Enhancing KCC2 function counteracts morphine-induced hyperalgesia.

Enhancing KCC2 function counteracts morphine-induced hyperalgesia.

Scientific reports (2017-06-22)

Francesco Ferrini, Louis-Etienne Lorenzo, Antoine G Godin, Miorie Le Quang, Yves De Koninck

ABSTRACT

Morphine-induced hyperalgesia (MIH) is a severe adverse effect accompanying repeated morphine treatment, causing a paradoxical decrease in nociceptive threshold. Previous reports associated MIH with a decreased expression of the Cl

MATERIALS

Product Number

Brand

Product Description

SML2172

Sigma-Aldrich

CLP290, ≥98% (HPLC)