Skip to Content
Merck
  • Analysis of endocrine disrupters and related compounds in sediments and sewage sludge using on-line turbulent flow chromatography-liquid chromatography-tandem mass spectrometry.

Analysis of endocrine disrupters and related compounds in sediments and sewage sludge using on-line turbulent flow chromatography-liquid chromatography-tandem mass spectrometry.

Journal of chromatography. A (2014-06-10)
Marina Gorga, Sara Insa, Mira Petrovic, Damià Barceló
ABSTRACT

A novel fully automated method based on dual column switching using turbulent flow chromatography followed by liquid chromatography coupled to tandem mass spectrometry (TFC-LC-MS/MS) was applied for the determination of endocrine disruptors (EDCs) and related compounds in sediment and sewage sludge samples. This method allows the unequivocal identification and quantification of the most relevant environmental EDCs such as natural and synthetic estrogens and their conjugates, antimicrobials, parabens, bisphenol A (BPA), alkylphenolic compounds, benzotriazoles, and organophosphorus flame retardants, minimizing time of analysis and alleviating matrix effects. Applying this technique, after the extraction of the target compounds by pressurized liquid extraction (PLE), sediment and sewage sludge extracts were directly injected to the chromatographic system and the analytes were concentrated into the clean-up loading column. Using six-port switching system, the analytes were transferred to the analytical column for subsequent detection by MS-MS (QqQ). In order to optimize this multiplexing system, a comparative study employing six types of TurboFlow™ columns, with different chemical modifications, was performed to achieve the maximum retention of analytes and best elimination of matrix components. Using the optimized protocol low limits of quantification (LOQs) were obtained ranging from 0.0083 to 1.6 ng/g for sediment samples and from 0.10 to 125 ng/g for sewage sludge samples (except for alkylphenol monoethoxylate). The method was used to evaluate the presence and fate of target EDCs in the Ebro River which is the most important river in Spain with intensive agricultural and industrial activities in the basin that contribute to deteriorating soil and water quality.

MATERIALS
Product Number
Brand
Product Description

Ethinylestradiol, British Pharmacopoeia (BP) Assay Standard
SKU
Pack Size
Availability
Price
Quantity
Sigma-Aldrich
Methanol, HPLC Plus, ≥99.9%, poly-coated bottles
SKU
Pack Size
Availability
Price
Quantity
USP
Estrone, United States Pharmacopeia (USP) Reference Standard
SKU
Pack Size
Availability
Price
Quantity
Supelco
Methanol, Pharmaceutical Secondary Standard; Certified Reference Material
SKU
Pack Size
Availability
Price
Quantity
Ethyl parahydroxybenzoate, European Pharmacopoeia (EP) Reference Standard
SKU
Pack Size
Availability
Price
Quantity
Ethinylestradiol, European Pharmacopoeia (EP) Reference Standard
SKU
Pack Size
Availability
Price
Quantity
Estrone, European Pharmacopoeia (EP) Reference Standard
SKU
Pack Size
Availability
Price
Quantity
USP
Ethinyl estradiol, United States Pharmacopeia (USP) Reference Standard
SKU
Pack Size
Availability
Price
Quantity
Methyl parahydroxybenzoate, European Pharmacopoeia (EP) Reference Standard
SKU
Pack Size
Availability
Price
Quantity
Sigma-Aldrich
Methanol, ACS reagent, ≥99.8%
SKU
Pack Size
Availability
Price
Quantity
Sigma-Aldrich
Methanol, puriss. p.a., ACS reagent, reag. ISO, reag. Ph. Eur., ≥99.8% (GC)
SKU
Pack Size
Availability
Price
Quantity
Sigma-Aldrich
Methanol, Laboratory Reagent, ≥99.6%
SKU
Pack Size
Availability
Price
Quantity
Sigma-Aldrich
Methanol, ACS spectrophotometric grade, ≥99.9%
SKU
Pack Size
Availability
Price
Quantity
Sigma-Aldrich
Methanol, ACS reagent, ≥99.8%
SKU
Pack Size
Availability
Price
Quantity
Sigma-Aldrich
Methanol, BioReagent, ≥99.93%
SKU
Pack Size
Availability
Price
Quantity
Sigma-Aldrich
Methanol, puriss., meets analytical specification of Ph Eur, ≥99.7% (GC)
SKU
Pack Size
Availability
Price
Quantity
Sigma-Aldrich
Methanol, Absolute - Acetone free
SKU
Pack Size
Availability
Price
Quantity
Sigma-Aldrich
Methanol, ACS reagent, ≥99.8%
SKU
Pack Size
Availability
Price
Quantity
Sigma-Aldrich
Methanol, suitable for HPLC, ≥99.9%
SKU
Pack Size
Availability
Price
Quantity
Sigma-Aldrich
Methanol, suitable for HPLC, gradient grade, ≥99.9%
SKU
Pack Size
Availability
Price
Quantity
Sigma-Aldrich
Methanol, HPLC Plus, ≥99.9%
SKU
Pack Size
Availability
Price
Quantity
Supelco
Estrone, Pharmaceutical Secondary Standard; Certified Reference Material
SKU
Pack Size
Availability
Price
Quantity
Supelco
Ethinyl Estradiol, Pharmaceutical Secondary Standard; Certified Reference Material
SKU
Pack Size
Availability
Price
Quantity
Sigma-Aldrich
17α-Ethynylestradiol, ≥98%
SKU
Pack Size
Availability
Price
Quantity
Sigma-Aldrich
Diethylstilbestrol, ≥99% (HPLC)
SKU
Pack Size
Availability
Price
Quantity
Sigma-Aldrich
Estrone, ≥99%
SKU
Pack Size
Availability
Price
Quantity
Sigma-Aldrich
4-tert-Octylphenol, 97%
SKU
Pack Size
Availability
Price
Quantity
Sigma-Aldrich
Benzyl 4-hydroxybenzoate, 99%
SKU
Pack Size
Availability
Price
Quantity
Sigma-Aldrich
Methanol, suitable for HPLC, gradient grade, 99.93%
SKU
Pack Size
Availability
Price
Quantity
Supelco
4-tert-Octylphenol, analytical standard
SKU
Pack Size
Availability
Price
Quantity