- Analysis of the disintegrin-metalloproteinases family reveals ADAM29 and ADAM7 are often mutated in melanoma.
Analysis of the disintegrin-metalloproteinases family reveals ADAM29 and ADAM7 are often mutated in melanoma.
Human mutation (2011-05-28)
Xiaomu Wei, Angela Moncada-Pazos, Santiago Cal, Clara Soria-Valles, Jared Gartner, Udo Rudloff, Jimmy C Lin, Steven A Rosenberg, Carlos López-Otín, Yardena Samuels
PMID21618342
ABSTRACT
We performed a mutational analysis of the 19 disintegrin-metalloproteinases (ADAMs) genes in human cutaneous metastatic melanoma and identified eight to be somatically mutated in 79 samples, affecting 34% of the melanoma tumors analyzed. Functional analysis of the two frequently mutated ADAM genes, ADAM29 and ADAM7 demonstrated that the mutations affect adhesion of melanoma cells to specific extracellular matrix proteins and in some cases increase their migration ability. This suggests that mutated ADAM genes could play a role in melanoma progression.
MATERIALS
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Sigma-Aldrich
ECM Cell Adhesion Array Kit, colorimetric, The ECM Cell Adhesion Array kit is useful for assessing specific cell surface integrins, monitoring in vitro cell differentiation, or screening potential cell adhesion promoters/inhibitors.