SML2709

Sphingosine 1-phosphate ready made solution

≥95% (TLC), Fully soluble 10mM solution

• Synonym(s): (2S,3R,4E)-2-Amino-4-octadecene-1,3-diol 1-phosphate, D-erythro-Sphingosine 1-phosphate, S1P
• Empirical Formula (Hill Notation): C₁₈H₃₈NO₅P
• Molecular Weight: 379.47
• UNSPSC Code: 12352200

Properties

• Quality Level: 100
• assay: ≥95% (TLC)
• form: liquid
• storage temp.: −20°C

Description

General description

Sphingosine 1-phosphate (S1P) is a sphingolipid derived from ceramide by an enzymatic reaction in vivo.¹ S1P acts as a signaling molecule by binding to G-protein coupled receptors (S1PR) (S1P1-5 receptors) which results in activation of small GTPases such as Ras, Rac Rho and further downstream intracellular effects such as PI-3-Kinase, Protein kinase C and Hippo signaling pathways. This generates an effect on cell migration, differentiation and survival and therefore effects variety of systems such as immune system, central nervous system and cardiovascular system.² For instance, S1P was found to inhibit cell apoptosis and induce cell proliferation by binding S1P1 to promote activation of ERK pathway.³ In addition, S1P was found to support cancer cells by inducing angiogenesis and survival of proliferative cells in the tumor microenvironment.⁴ Due to the vast activities of S1P and the resulted S1PR irregular activation, large discovery efforts are made to identify therapy by S1PR antagonists.⁵

Biochem/physiol Actions

Anti angigoenesis

Other Notes

Sphingosine 1-phosphate ready made solution is supplied in aqueous solution at 10mM concentration and can be further diluted (X10000) to a working concentration of 1μM.

Safety Information

• Storage Class: 12 - Non Combustible Liquids
• wgk_germany: WGK 2
• flash_point_f: Not applicable
• flash_point_c: Not applicable