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Key Documents

SAB5200102

Sigma-Aldrich

Anti-SLC9A3 antibody produced in rabbit

1 mg/mL, affinity isolated antibody

Synonym(s):

Anti-NHE3, Anti-Slc9a3

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous glycerol solution

mol wt

antigen predicted mol wt 84 kDa

species reactivity

rat, mouse

concentration

1 mg/mL

technique(s)

immunocytochemistry: suitable
western blot: suitable

NCBI accession no.

NP_036786

UniProt accession no.

P26433

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

rat ... Slc9a3(24784)

General description

Solute carrier family 9 member A3 (SLC9A3) is also known as Na+/H+ exchanger 3 (NHE3) and is expressed in the brush border epithelium. The gene ID of the protein is 24784.

Specificity

Detects ~84 kDa.

Immunogen

AA809 to 831 of rat sequence

Biochem/physiol Actions

Solute carrier family 9 member A3 (SLC9A3) is an exchanger which takes part in the reabsorption of water and sodium chloride in the proximal tubule of kidneys. It exchanges one Na+ (from the lumen) with one H+ (from the cytosol).

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

PBS, 50% glycerol, and 0.09% sodium azide

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Srinivas Rengarajan et al.
American journal of physiology. Renal physiology, 306(9), F1059-F1068 (2014-03-07)
Dietary potassium loading results in rapid kaliuresis, natriuresis, and diuresis associated with reduced phosphorylation (p) of the distal tubule Na(+)-Cl(-) cotransporter (NCC). Decreased NCC-p inhibits NCC-mediated Na(+) reabsorption and shifts Na(+) downstream for reabsorption by epithelial Na(+) channels (ENaC), which
Jens Christian Brasen et al.
American journal of physiology. Renal physiology, 307(11), F1249-F1262 (2014-10-10)
The proximal tubule Na(+)/H(+) exchanger 3 (NHE3), located in the apical dense microvilli (brush border), plays a major role in the reabsorption of NaCl and water in the renal proximal tubule. In response to a rise in blood pressure NHE3

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