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S2067

Sigma-Aldrich

S9 from Liver, Pooled

from rat(Sprague-Dawley), male

Synonym(s):

Liver S9 Fraction, S9 Liver Extract

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About This Item

UNSPSC Code:
12161501
NACRES:
NA.47

biological source

rat (Sprague-Dawley)

Quality Level

200

packaging

vial of ~20 mg

UniProt accession no.

B0BN68

shipped in

dry ice

storage temp.

−70°C

Gene Information

rat ... Mrps9(301371)

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Application

S9 from Liver, Pooled has been used in metabolic activation in Salmonella typhimurium strains.

Biochem/physiol Actions

The hepatic S9 pools from a variety of biological sources represent the post-mitochondrial supernatant fraction from homogenized liver. Known to be a rich source of drug metabolizing enzymes including P-450, these pools are useful in the study of xenobiotic metabolism and drug interactions.
They are used in the Ames test, which is a method that uses bacteria to test if a given chemical causes mutations in the genetic material of a given test organism.

Storage Class

10 - Combustible liquids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Genotoxicity evaluation of locally produced dental porcelain-An in vitro study using the Ames and Comet assays
Noushad M, et al.
Toxicology in vitro, 23(6), 1145-1150 (2009)
The Ames Salmonella/microsome mutagenicity assay.
Mortelman K and Zeiger E
Mutation Research, 455(1-2), 29-60 (2000)
An improvement of the Ames test using a modified human liver S9 preparation.
Hakura A
Journal of Pharmacological and Toxicological Methods, 46(3), 169-172 (2001)
Milena Lopes Francisco Bittencourt et al.
Life sciences, 256, 117977-117977 (2020-07-01)
Silibinin is the major component of flavonolignans complex mixture (Silymarin), which is obtained from Silybum marianum (L.) Gaertn. Despite several reports about silibinin, little is known about its effects on gastric diseases. Then, the present study aims to evaluate the
Leonara Fayer et al.
Toxicology research, 10(3), 511-522 (2021-06-19)
The titanium dioxide nanoparticles (NPs) have been applied to biomedical, pharmaceutical, and food additive fields. However, the effect on health and the environment are conflicting; thus, it has been reviewing several times. In this context, establishing standard robust protocols for

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