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N7287

Sigma-Aldrich

NU-1025

≥97% (HPLC), solid

Synonym(s):

8-Hydroxy-2-methylquinazolin-4[3H]-one

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About This Item

Empirical Formula (Hill Notation):
C9H8N2O2
CAS Number:
90417-38-2
Molecular Weight:
176.17
MDL number:
MFCD00942555
UNSPSC Code:
12352200
PubChem Substance ID:
24724555
NACRES:
NA.77

Quality Level

100

assay

≥97% (HPLC)

form

solid

color

off-white

solubility

DMSO: soluble >20 mg/mL
H2O: insoluble

storage temp.

−20°C

SMILES string

CC1=Nc2c(O)cccc2C(=O)N1

InChI

1S/C9H8N2O2/c1-5-10-8-6(9(13)11-5)3-2-4-7(8)12/h2-4,12H,1H3,(H,10,11,13)

InChI key

YJDAOHJWLUNFLX-UHFFFAOYSA-N

Gene Information

mouse ... Parp2(11546)

Biochem/physiol Actions

NU-1025 is a PARP inhibitor.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

ppe

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

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Quanju Zhao et al.
Journal of immunology (Baltimore, Md. : 1950), 198(7), 2935-2942 (2017-02-22)
IL-12 and IL-23 are important host defense factors produced by APCs against certain intracellular and extracellular pathogens. Their dysregulation has also been implicated in several autoimmune diseases. The nucleotide polymorphism in the promoter region of Il12b (rs41292470 consisting of the
David Zada et al.
Molecular cell, 81(24), 4979-4993 (2021-11-20)
The characteristics of the sleep drivers and the mechanisms through which sleep relieves the cellular homeostatic pressure are unclear. In flies, zebrafish, mice, and humans, DNA damage levels increase during wakefulness and decrease during sleep. Here, we show that 6 h
Michael M Murata et al.
Molecular biology of the cell, 30(20), 2584-2597 (2019-08-08)
DNA damage signaling is critical for the maintenance of genome integrity and cell fate decision. Poly(ADP-ribose) polymerase 1 (PARP1) is a DNA damage sensor rapidly activated in a damage dose- and complexity-dependent manner playing a critical role in the initial
Yang Sun et al.
American journal of respiratory cell and molecular biology, 51(6), 738-749 (2014-05-31)
Lymphangioleiomyomatosis (LAM) is a female-predominant cystic lung disease that can lead to respiratory failure. LAM cells typically have inactivating tuberous sclerosis complex 2 (TSC2) mutations and mammalian target of rapamycin (mTOR) complex (mTORC) 1 activation. Clinical response to the mTORC1

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