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E1900000

Ethinylestradiol

European Pharmacopoeia (EP) Reference Standard

Synonym(s):

17α-Ethynylestradiol, 17α-Ethynyl-1,3,5(10)-estratriene-3,17β-diol, 19-Nor-1,3,5(10),17α-pregnatrien-20-yne-3,17-diol, Ethinylestradiol

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About This Item

Empirical Formula (Hill Notation):
C20H24O2
CAS Number:
57-63-6
Molecular Weight:
296.40
Beilstein/REAXYS Number:
2419975
MDL number:
MFCD00003690
UNSPSC Code:
41116107
PubChem Substance ID:
329799022
NACRES:
NA.24

grade

pharmaceutical primary standard

API family

ethinyl estradiol

manufacturer/tradename

EDQM

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

mp

182-183 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

SMILES string

[H][C@]12CC[C@@]3(C)[C@@]([H])(CC[C@@]3(O)C#C)[C@]1([H])CCc4cc(O)ccc24

InChI

1S/C20H24O2/c1-3-20(22)11-9-18-17-6-4-13-12-14(21)5-7-15(13)16(17)8-10-19(18,20)2/h1,5,7,12,16-18,21-22H,4,6,8-11H2,2H3/t16-,17-,18+,19+,20+/m1/s1

InChI key

BFPYWIDHMRZLRN-SLHNCBLASA-N

Gene Information

human ... ESR1(2099)

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General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Ethinylestradiol EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

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Danger

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Chronic 1 - Carc. 2 - Repr. 1A

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk_germany

WGK 3

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C Piérard-Franchimont et al.
Maturitas, 22(2), 151-154 (1995-09-01)
The effects of menopause and hormone replacement therapy (HRT) on the epidermis are largely unknown. The aim of this study was to model and measure the influence of estrogen-transdermal HRT on subtle physiological changes taking place in the epidermis during
Bernardine H Stegeman et al.
BMJ (Clinical research ed.), 347, f5298-f5298 (2013-09-14)
To provide a comprehensive overview of the risk of venous thrombosis in women using different combined oral contraceptives. Systematic review and network meta-analysis. PubMed, Embase, Web of Science, Cochrane, Cumulative Index to Nursing and Allied Health Literature, Academic Search Premier
Konrad F Koehler et al.
Endocrine reviews, 26(3), 465-478 (2005-04-29)
We have known for many years that estrogen is more than the female hormone. It is essential in the male gonads, and in both sexes, estrogen has functions in the skeleton and central nervous system, on behavior, and in the
Jie Han et al.
Water research, 47(7), 2273-2284 (2013-03-08)
This study demonstrates that ethinylestradiol (EE2), a priority estrogenic contaminant in water, can be rapidly and selectively removed from aqueous solutions using industrial-grade polyamide 612 (PA612) particles as adsorbents. Isothermal studies showed that nonporous low surface area (20 m(2) g(-1)) PA612 particles
A Frølich et al.
Bone, 11(6), 393-396 (1990-01-01)
An attempt was made to explain the bone-preserving effect of estrogen by analysis of estrogen receptors (OER) in the calcitonin-producing C-cells of the human thyroid gland. Thyroid tissue from twenty patients with benign hyperthyroidism and three patients with medullary thyroid
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