MAB416
Anti-Interferon-β Antibody, clone A1
clone A1, Chemicon®, from mouse
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About This Item
UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Recommended Products
biological source
mouse
Quality Level
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
A1, monoclonal
species reactivity
human
manufacturer/tradename
Chemicon®
technique(s)
ELISA: suitable
western blot: suitable
isotype
IgGκ
NCBI accession no.
UniProt accession no.
shipped in
dry ice
target post-translational modification
unmodified
Gene Information
human ... IFNB1(3456)
Specificity
Human interferon-beta (IFN-beta). Recognizes amino acids 30-47 of IFN-beta. No cross-reactivity with Human IFN-alpha or IFN-gamma.
Immunogen
Human interferon beta.
Application
Anti-Interferon-β Antibody, clone A1 detects level of Interferon-β & has been published & validated for use in ELISA & WB.
Immunoblotting
ELISA
Neutralization of IFN-beta bioactivity; 90% reduction of bioactivity at 1.4 μg/mL for recombinant IFN-beta and 2.7 μg/mL for natural IFN-beta. Assay method used is provided in Grossberg, S.E. et al, Manual of Clinical Immunology.
Optimal working dilutions must be determined by the end user.
ELISA
Neutralization of IFN-beta bioactivity; 90% reduction of bioactivity at 1.4 μg/mL for recombinant IFN-beta and 2.7 μg/mL for natural IFN-beta. Assay method used is provided in Grossberg, S.E. et al, Manual of Clinical Immunology.
Optimal working dilutions must be determined by the end user.
Research Category
Inflammation & Immunology
Inflammation & Immunology
Research Sub Category
Cytokines & Cytokine Receptors
Cytokines & Cytokine Receptors
Physical form
Format: Purified
Hybridoma culture grown in low IgG FBS (3%), Protein G purified. Liquid in 50 mM Na Acetate, pH 6.5, 50 mM NaCl, 4% sucrose, 0.1% Tween20, no preservatives added
Storage and Stability
Maintain at -20°C in undiluted aliquots for up to twelve months after date of receipt. Avoid repeated freeze/thaw cycles.
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Legal Information
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Description
Pricing
Storage Class
12 - Non Combustible Liquids
wgk_germany
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Find documentation for the products that you have recently purchased in the Document Library.
Neutralizing antibodies to interferon beta in multiple sclerosis: analytical evaluation for validation of a cytopathic effect assay.
Catherine Massart,Jacqueline Gibassier,Joel Oger,Emmanuelle Le Page,Gilles Edan
Clinica Chimica Acta; International Journal of Clinical Chemistry null
Analysis of antigenic domains on natural and recombinant human IFN-beta by the inhibition of biologic activities with monoclonal antibodies.
Redlich, P N and Grossberg, S E
Journal of immunology (Baltimore, Md. : 1950), 143, 1887-1893 (1989)
Reduced effectiveness of long-term interferon-beta treatment on relapses in neutralizing antibody-positive multiple sclerosis patients: a Canadian multiple sclerosis clinic-based study.
C Boz,J Oger,E Gibbs,S E Grossberg,
Multiple Sclerosis (Houndmills, Basingstoke, England) null
Antiviral gene expression in rheumatoid arthritis: role of IKKepsilon and interferon regulatory factor 3.
Susan E Sweeney,Ling Mo,Gary S Firestein
Arthritis and Rheumatism null
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