8.17072

TWEEN^® 20 (Polysorbate)

EMPROVE^® ESSENTIAL, Ph. Eur., JPE, NF

• Synonym(s): TWEEN^® 20, Polyethylene glycol sorbitan monolaurate, Polyoxyethylenesorbitan monolaurate
• CAS Number: 9005-64-5
• MDL number: MFCD00165986
• UNSPSC Code: 12352104
• EC Index Number: 500-018-3

Properties

• agency: JPE; NF; Ph. Eur.
• Quality Level: 500
• vapor pressure: <1.4 hPa ( 20 °C)
• product line: EMPROVE^® ESSENTIAL
• form: viscous liquid
• mol wt: ~1228
• technique(s): API processing | nano-milling: suitable
• refractive index: n20/D 1.468 (lit.)
• pH: 6-8 (20 °C, 50 g/L in H₂O)
• transition temp: flash point 275 °C
• density: 1.095 g/mL at 25 °C (lit.)
• application(s): liquid formulation; ophthalmics; pharma/biopharma processes; pharmaceutical; semi-solid formulation; solid formulation; solubility enhancement
• storage temp.: 15-25°C
• SMILES string: CCCCCCCCCCCC(=O)OCCOCC(C1C(C(CO1)OCCO)OCCO)OCCO
• InChI: 1S/C26H50O10/c1-2-3-4-5-6-7-8-9-10-11-24(30)34-19-18-31-20-22(32-15-12-27)26-25(35-17-14-29)23(21-36-26)33-16-13-28/h22-23,25-29H,2-21H2,1H3
• InChI key: HMFKFHLTUCJZJO-UHFFFAOYSA-N

Description

General description

Finding the right excipient that matches your needs as well as regulatory demands can be a complicated challenge in formulation. With our application know-how and regulatory expertise, we support you in every step of development, scale-up, and production.
As part of our Emprove^® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC^® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

Application

Polysorbate 20 is used as surfactant in a variety of liquid formulations and acts e.g. as emulsifying, solubilizing and wetting agent.

Non-ionic detergent

Legal Information

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany

SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

TWEEN is a registered trademark of Croda International PLC

Safety Information

• Storage Class: 10 - Combustible liquids
• wgk_germany: WGK 1
• flash_point_f: 527.0 °F - Pensky-Martens closed cup
• flash_point_c: 275 °C - Pensky-Martens closed cup