553031

RAGE Antagonist Peptide, RAP

The RAGE Antagonist Peptide, RAP controls the biological activity of RAGE.

• Synonym(s): RAGE Antagonist Peptide, RAP, ELKVLMEKEL
• Empirical Formula (Hill Notation): C₅₇H₁₀₁N₁₃O₁₇S
• Molecular Weight: 1272.55
• UNSPSC Code: 12352111
• NACRES: NA.77

Properties

• Quality Level: 200
• assay: ≥95% (HPLC)
• form: powder
• potency: 2 μM IC₅₀
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; protect from light
• color: white
• solubility: water: 5 mg/mL
• shipped in: dry ice
• storage temp.: −20°C

Description

General description

An S100P-derived peptide based competitive antagonist for receptor for advanced glycation end product (RAGE). Shown to disrupt the interaction between RAGE and its ligands, such as S100P, S100A4 and HMGB-1 in binding assays and in multiple cancer cell lines (~2 µM). Also, blocks RAGE-dependent NF-kB activation in MPanc96, MOH and HPAF II tumor cell lines. Systemic administration of RAP also diminishes NF-kB signaling in vivo and significantly reduces glioma tumor growth in murine models.

Biochem/physiol Actions

Primary Target
RAGE

Reversible: yes

Packaging

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Sequence

Ac-ELKVLMEKEL-NH2

Physical form

Supplied as a trifluoroacetate salt.

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Arumugam, T., et al. 2012. Clin Cancer Res.18, 4356.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable