5.05986

SR95531 (Gabazine)

• Synonym(s): SR95531 (Gabazine), GABA _A Receptor Antagonist, SR-95531, Gabazine, SR95531, SR 95531, GABA_A Receptor Antagonist, SR-95531, Gabazine, SR95531, SR 95531
• Empirical Formula (Hill Notation): C₁₅H₁₇N₃O₃ · xHBr
• CAS Number: 104104-50-9
• Molecular Weight: 287.31 (free base basis)
• MDL number: MFCD00055135
• UNSPSC Code: 12352200

Properties

• assay: ≥98% (HPLC)
• Quality Level: 100
• form: solid
• potency: 440 nM IC₅₀
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; protect from light
• color: white
• solubility: water: 25 mM
• storage temp.: 2-8°C
• InChI: 1S/C15H17N3O3.BrH/c1-21-12-6-4-11(5-7-12)13-8-9-14(16)18(17-13)10-2-3-15(19)20;/h4-9,16H,2-3,10H2,1H3,(H,19,20);1H
• InChI key: GFZHNFOGCMEYTA-UHFFFAOYSA-N

Description

General description

A selective, competitive antagonist of GABA_A receptor (IC₅₀ = 440 nM) that does not affect pentobarbitone or etomidate- induced currents even at high concentrations (~100 µM). Also shown to block glycine receptors, but with low affinity (K_b = 190 µM).

A selective, competitive antagonist of GABA_A receptor (IC₅₀ = 440 nM) that does not affect pentobarbitone or etomidate- induced currents even at high concentrations (~100 mM). Also shown to block glycine receptors, but with low affinity (K_b = 190 mM).

Biochem/physiol Actions

Primary Target
GABA_A

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Muroi, Y., et al. 2009. Biophys. J.96, 499.
Beato, M., et al. 2007. J. Physiol.580, 171.
Uchida, I., et al. 1996. Eur. J. Pharmacol.307, 89.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable