218767

Caspase-6 Inhibitor II, Cell-Permeable

The Caspase-6 Inhibitor II, Cell-Permeable controls the biological activity of Caspase-6. This small molecule/inhibitor is primarily used for Cancer applications.

• Synonym(s): Caspase-6 Inhibitor II, Cell-Permeable, VEID-CHO, Cell-permeable; sequence
• Empirical Formula (Hill Notation): C₉₆H₁₆₄N₂₀O₂₅
• Molecular Weight: 1998.45
• UNSPSC Code: 12352200
• NACRES: NA.77

Properties

• Quality Level: 100
• assay: ≥97% (HPLC)
• form: lyophilized solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; desiccated (hygroscopic)
• solubility: DMSO: 5 mg/mL
• shipped in: ambient
• storage temp.: −20°C

Description

General description

A potent, cell-permeable, and reversible inhibitor of caspase-6.The N-terminal sequence (amino acids 1-16) corresponds to the hydrophobic region of the signal peptide of Kaposi fibroblast growth factor and confers cell permeability to the peptide.

Potent, cell-permeable and reversible inhibitor of caspase-6.

Biochem/physiol Actions

Cell permeable: yes

Primary Target
caspase-6

Product does not compete with ATP.

Reversible: yes

Warning

Toxicity: Standard Handling (A)

Sequence

Ac-Ala-Ala-Val-Ala-Leu-Leu-Pro-Ala-Val-Leu-Leu-Ala-Leu-Leu-Ala-Pro-Val-Glu-Ile-Asp-CHO

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Hirata, H., et al. 1998. J. Exp. Med. 187, 587.
Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable