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Key Documents

420336

Sigma-Aldrich

2-Chloro-1,3-dimethylimidazolidinium hexafluorophosphate

98%

Synonym(s):

2-Chloro-4,5-dihydro-1,3-dimethyl-1H-imidazolium hexafluorophosphate, CIP

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About This Item

Empirical Formula (Hill Notation):
C5H10ClF6N2P
CAS Number:
Molecular Weight:
278.56
Beilstein/REAXYS Number:
5369058
MDL number:
UNSPSC Code:
12352101
PubChem Substance ID:
NACRES:
NA.22

Quality Level

assay

98%

reaction suitability

reaction type: Coupling Reactions

mp

231-233 °C (lit.)

application(s)

peptide synthesis

SMILES string

F[P-](F)(F)(F)(F)F.CN1CC[N+](C)=C1Cl

InChI

1S/C5H10ClN2.F6P/c1-7-3-4-8(2)5(7)6;1-7(2,3,4,5)6/h3-4H2,1-2H3;/q+1;-1

InChI key

CNAKHAGVVMOXFE-UHFFFAOYSA-N

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Application

Reactant for synthesis of:
Diazo-transfer reagents

Reagent for synthesis of:
Cannabinoid CB1 receptor agonists
Selective small-molecule melanocortin-4 receptor agonists
Imidazoles as selective cannabinoid CB2 receptor antagonists
Cyclic alpha-peptoids
Cyclic melanotropin peptide analogues selective for the human melanocortin-4 receptor

pictograms

Exclamation mark

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves


Certificates of Analysis (COA)

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Articles

N-Acylimidazoles were recognized in the early 1950s as reactive intermediates suitable for the acylation of amino compounds. The search for better coupling reagents than DCC led to the development of CDI (1,1’-carbonyldiimidazole) and related carbonylimidazoles.

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