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Key Documents
SML1751
GSK591
≥97% (HPLC)
Synonim(y):
2-(Cyclobutylamino)-N-[(2S)-3-(3,4-dihydro-2(1H)-isoquinolinyl)-2-hydroxypropyl]-4-pyridinecarboxamide., EPZ015866, GSK 591, GSK3203591
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About This Item
Wzór empiryczny (zapis Hilla):
C22H28N4O2
Numer CAS:
Masa cząsteczkowa:
380.48
Numer MDL:
Kod UNSPSC:
12352200
Identyfikator substancji w PubChem:
NACRES:
NA.77
Polecane produkty
Poziom jakości
Próba
≥97% (HPLC)
Postać
powder
kolor
white to beige
rozpuszczalność
DMSO: 20 mg/mL, clear
temp. przechowywania
2-8°C
ciąg SMILES
O=C(NC[C@H](O)CN1CCC(C=CC=C2)=C2C1)C3=CC=NC(NC4CCC4)=C3
Działania biochem./fizjol.
GSK591 is a SGC probe for PRMT5. GSK591 is a potent and selective inhibitor of H4 histone methylation by PRMT5/MEP50 complex. For full characterization details, please visit the GSK591 probe summary on the Structural Genomics Consortium (SGC) website.
SGC2096 is the negative control for the active probe, GSK-591. To request a sample of the negative control from the SGC, click here.
To learn about other SGC chemical probes for epigenetic targets, visit sigma.com/sgc
SGC2096 is the negative control for the active probe, GSK-591. To request a sample of the negative control from the SGC, click here.
To learn about other SGC chemical probes for epigenetic targets, visit sigma.com/sgc
GSK591 is also known as 2-(cyclobutylamino)-N-[(2S)-3-(3,4-dihydro-2(1H)-isoquinolinyl)-2-hydroxypropyl]-4-pyridinecarboxamide, EPZ015866 and GSK3203591. It prevents the systemic arginine methylation of SmD3 (small nuclear ribonucleoprotein).
Cechy i korzyści
GSK591 is an epigenetic chemical probe available through a partnership with the Structural Genomics Consortium (SGC). To learn more and view other SGC epigenetic probes, visit sigma.com/SGC.
This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
Inne uwagi
GSK591 has been expertly reviewed and recommended by the Chemical Probes Portal. For more information, please visit the GSK591 probe summary on the Chemical Probes Portal website.
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Kod klasy składowania
11 - Combustible Solids
Klasa zagrożenia wodnego (WGK)
WGK 3
Temperatura zapłonu (°F)
Not applicable
Temperatura zapłonu (°C)
Not applicable
Certyfikaty analizy (CoA)
Poszukaj Certyfikaty analizy (CoA), wpisując numer partii/serii produktów. Numery serii i partii można znaleźć na etykiecie produktu po słowach „seria” lub „partia”.
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Juan Dong et al.
Nature communications, 10(1), 4705-4705 (2019-10-19)
DNA methylation, repressive histone marks, and PIWI-interacting RNA (piRNA) are essential for the control of retrotransposon silencing in the mammalian germline. However, it remains unknown how these repressive epigenetic pathways crosstalk to ensure retrotransposon silencing in the male germline. Here
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Communications biology, 5(1), 313-313 (2022-04-07)
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Coralie Poulard et al.
Methods (San Diego, Calif.), 175, 66-71 (2019-09-10)
Arginine methylation is now recognized as a major contributor to proteome diversity and is, as such, involved in a large range of cellular processes. There is a growing need for assessing endogenous protein arginine methylation in cells. Besides the classical
Carolin Dorothea Strobl et al.
Molecular cancer therapeutics, 19(2), 409-419 (2019-11-13)
Genetic alterations in tumor cells provide promising targets for antitumor therapy. Recently, loss of methylthioadenosine phosphorylase (MTAP), a deletion frequently occurring in cancer, has been shown to create vulnerability to the inhibition of the protein arginine methyltransferase 5 (PRMT5). MTAP
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