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SML1018

Sigma-Aldrich

Cyclosporin A

≥95% (HPLC), DMSO solution, calcineurin inhibitor

Synonim(y):

CsA, Cyclosporine

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About This Item

Wzór empiryczny (zapis Hilla):
C62H111N11O12
Numer CAS:
59865-13-3
Masa cząsteczkowa:
1202.61
Numer WE:
200-664-3
Kod UNSPSC:
12352200
NACRES:
NA.77

product name

Cyclosporin A, Ready Made Solution, 1 mg/mL in DMSO

Postać

DMSO solution

Poziom jakości

200

warunki przechowywania

protect from light

stężenie

1 mg/mL in DMSO

Warunki transportu

dry ice

temp. przechowywania

−20°C

InChI

1S/C62H111N11O12/c1-25-27-28-40(15)52(75)51-56(79)65-43(26-2)58(81)67(18)33-48(74)68(19)44(29-34(3)4)55(78)66-49(38(11)12)61(84)69(20)45(30-35(5)6)54(77)63-41(16)53(76)64-42(17)57(80)70(21)46(31-36(7)8)59(82)71(22)47(32-37(9)10)60(83)72(23)50(39(13)14)62(85)73(51)24/h25,27,34-47,49-52,75H,26,28-33H2,1-24H3,(H,63,77)(H,64,76)(H,65,79)(H,66,78)/b27-25+

Klucz InChI

PMATZTZNYRCHOR-IMVLJIQESA-N

Zastosowanie

Cyclosporin A has been used to test its toxic effect on perfused 3D proximal tubule model.

Działania biochem./fizjol.

Cyclosporin A is a non-polar cyclic oligopeptide produced by the fungus Tolypocladium inflatum. It is a potent immunosuppressive agent, affecting primarily T-lymphocytes. It has been shown to inhibit the functioning of several nuclear proteins involved in T-cell activation at the level of mRNA transcription. It forms a complex with its intracellular receptor cyclophilin, which can then bind to calcineurin, a Ca2+- and calmodulin-dependent protein phosphatase, inhibiting its enzymatic activity. CsA was found to suppress the replication of hepatitis C virus genome in cultured hepatocytes. At concentrations >10 nM, CsA protected isolated hepatocytes against the action of phalloidin. CsA can inhibit IL2 production resulting from T cell activation via Calcineurin inhibition.
An extensive list of references has been reported, including a comprehensive review of analytical properties.
Cyclosporin A is generally given subsequent to transplant surgery to prevent rejection. In addition to its beneficial effects in organ transplantation, cyclosporin (CyA) exhibits nephrotoxic side effects.

Inne uwagi

Light sensitive
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Kod klasy składowania

10 - Combustible liquids

Klasa zagrożenia wodnego (WGK)

WGK 1

Temperatura zapłonu (°F)

188.6 °F - closed cup

Temperatura zapłonu (°C)

87 °C - closed cup

Certyfikaty analizy (CoA)

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